European partnership for pandemic preparedness

Code: 33514 | Identifier Code: HORIZON-HLTH-2024-DISEASE-12-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 25/04/2024 | End submission calls: 26/11/2024

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 3 “Tackling diseases and reducing disease burden”.

The partnership will be firmly anchored within the framework of the European Health Union package that aims to improve the EU’s capacity in the vital areas of prevention, preparedness, surveillance, risk assessment, early warning, and response.

Transformative investments in research for pandemic preparedness are needed at European level. Stronger collaboration and coordination between European actors, including the appropriate infrastructures and networks, are an important prerequisite for improving EU’s pandemic preparedness and stepping up our contribution to global cooperation in this area.

Pre-commercial procurement for environmentally sustainable, climate neutral and circular health and care systems

Code: 33511 | Identifier Code: HORIZON-HLTH-2024-CARE-14-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 25/04/2024 | End submission calls: 26/11/2024

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 4 “Ensuring access to innovative, sustainable and high-quality health care”.

Good hygiene and safety are vital in this setting however innovative solutions can help to reduce the environmental impact of the healthcare sector through the efficient use of resources, increasing circularity, and the introduction of “greener” materials, technologies and practices. The declaration calls for action and joint vision on ensuring better health outcomes, in part through the transformation of health and care systems to become climate-resilient, low-carbon, sustainable, circular and equitable. Such a transformation will contribute in the long term to improving patient care by enhancing both the sustainability and overall efficiency of health and care systems.

European Partnership: One Health Anti-Microbial Resistance

Code: 33508 | Identifier Code: HORIZON-HLTH-2024-DISEASE-09-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 25/04/2024 | End submission calls: 25/09/2024

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 3 “Tackling diseases and reducing disease burden”.

The partnership should contribute to the priorities set in the European One Health Action plan to fight AMR and in the Council Recommendation on stepping up EU actions to combat antimicrobial resistance in a One Health approach that provide European frameworks with actions and objectives focused on areas with the highest added value for Member States, including boosting research development and innovation.

Implementation research for management of multiple long-term conditions in the context of non-communicable diseases (Global Alliance for Chronic Diseases - GACD)

Code: 33506 | Identifier Code: HORIZON-HLTH-2024-DISEASE-13-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 25/04/2024 | End submission calls: 26/11/2024

The topic is focused on implementation research for management of multiple long-term conditions in the context of non-communicable diseases (NCDs) (MLTC NCD) in LMICs and/or disadvantaged populations in HICs. Proposals should focus on implementation science around interventions that will generate evidence about when, for whom, and under what circumstances, patient-centred approaches can improve integrated care for patients with MLTC NCD.

Pandemic preparedness and response: Maintaining and enhancing the preparatory work for a co-funded European partnership for pandemic preparedness

Code: 33498 | Identifier Code: HORIZON-HLTH-2024-DISEASE-17-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 25/04/2024 | End submission calls: 30/05/2024

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 3 “Tackling diseases and reducing disease burden”.
The COVID-19 pandemic illustrated how unilateral research initiatives may lead to a fragmented research landscape, with substantial room for efficiency gains in the development of the highly needed evidence to guide policy actions when facing an emergency.
A coordination and support action is working towards improving the EU’s preparedness to predict and respond to emerging infectious health threats by better coordinating funding for research and innovation at EU, national (and regional) level towards common objectives and an agreed Strategic Research and Innovation Agenda.

Bio-printing of living cells for regenerative medicine

Code: 31415 | Identifier Code: HORIZON-HLTH-2024-TOOL-11-02 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 26/10/2023 | End submission calls: 11/04/2024

This topic focuses on bioprinting of living cells for regenerative medicine.

Moreover, 3D printing is generally considered advanced technical manufacturing and 3D analytical printing of non-viable biomaterials to serve e.g. as a scaffold for cell growth or as a structure for medical devices that are already widely used.

However, bioprinting technology involving living cells is still in its infancy, but has enormous potential for tissue engineering, drug testing, and other biomedical applications. Tissue-specific functional 3D bioprinting is a new approach for transformative applications in regenerative medicine, based on the fabrication of tissues and organs with respect to their desired shape and function and implementation in vivo.

Pandemic preparedness and response: Hostpathogen interactions of infectious diseases with epidemic potential

Code: 31413 | Identifier Code: HORIZON-HLTH-2024-DISEASE-08-20 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 26/10/2023 | End submission calls: 11/04/2024

Viral disease emergence is expected to accelerate due to among other factors, climate change, and thus a proactive approach to the development of vaccines and inhibitors for the cellular uptake of viruses in preparedness for future infectious disease outbreaks is needed. The availability of vaccines and candidates that inhibit cellular uptake of viruses would provide a critical preparedness measure against future health threats, in particular against pathogens with high pandemic potential meeting the criteria identified by the Health Emergency Preparedness and Response Authority (HERA).

Proposals should follow innovative approaches to characterise host-pathogen interactions with a view to inhibit viral replication, viral proteases, viral exit strategies and to develop therapeutic antibodies and vaccines that target viruses with high epidemic or pandemic potential for the EU. Proposals should focus on the following viruses: Hendra and Nipah virus, Lassa virus, Crimean Congo haemorrhagic fever virus, Rift Valley fever virus, Ebola and Marburg virus, Dengue virus, Yellow Fever virus, Zika virus, West Nile fever virus and Chikungunya virus. Proposal should take into account sex and gender aspects.

Proposals should aim to diversify and accelerate the global therapeutic research and development pipeline for emerging and re-emerging viral infections, and to strengthen the current leading role of the EU in therapeutic research and development, and therefore contributing to the work of the European Health Emergency Preparedness and Response Authority (HERA).

Pandemic preparedness and response: Maintaining the European partnership for pandemic preparedness

Code: 31410 | Identifier Code: HORIZON-HLTH-2024-DISEASE-08-12 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 26/10/2023 | End submission calls: 11/04/2024

The European partnership for pandemic preparedness is working to improve the EU’s preparedness to predict and respond to emerging infectious health threats by better coordinating funding for research and innovation at EU, national (and regional) level towards common objectives and an agreed Strategic Research and Innovation Agenda. Such a partnership contributes to building a coherent European Research Area (ERA), enabling Member States, Associated Countries and the European Commission to rapidly and jointly support research and innovation in pandemic preparedness.

Gaining experience and confidence in New Approach Methodologies (NAM) for regulatory safety and efficacy testing – coordinated training and experience exchange for regulators

Code: 31407 | Identifier Code: HORIZON-HLTH-2024-IND-06-09 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 26/10/2023 | End submission calls: 11/04/2024

The proposals should focus on alternatives to the use of animals for regulatory safety and efficacy testing. Applicants should propose activities that bring together NAM developers and NAM users with European regulators responsible for the safe use of chemicals (e.g. industrial chemicals, pesticides, biocides and cosmetics) and pharmaceuticals in order to inform on NAM solutions available and to encourage the building of a framework on how these NAMs could be most effectively used in the different decision-making contexts. For NAMs applicable to chemical risk assessment, collaboration with existing initiatives such as the Partnership for the Assessment of Risks from Chemicals (PARC) and the ASPIS cluster of projects (Animal-free Safety Assessment of chemicals: Project cluster for Implementation of novel Strategies) is encouraged.

Developing EU methodological frameworks for clinical/performance evaluation and post-market clinical/performance follow-up of medical devices and in vitro diagnostic medical devices (IVDs)

Code: 31404 | Identifier Code: HORIZON-HLTH-2024-IND-06-08 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 26/10/2023 | End submission calls: 11/04/2024

The Medical Device Regulation (MDR) and in vitro diagnostic medical device Regulation (IVDR) provides a new regulatory framework where reinforcement of clinical/performance evaluation of medical devices and IVDs, and in particular high-risk medical devices, is a key element. The confirmation of conformity with the relevant general safety and performance requirements set out in the MDR and IVDR is based on clinical data and its assessment (clinical/performance evaluation), including the evaluation of the acceptability of the benefit-risk- ratio. Within this new framework, the clinical/performance evaluation should follow a defined and methodologically sound procedure based on the critical evaluation of the relevant scientific literature, a critical evaluation of the results of all available clinical investigations/performance studies, as well as consideration of currently available alternative treatment options for the device under evaluation. Clinical/performance evaluation has to be updated throughout the life cycle of the device. Hence, clinical/performance evaluation can draw on multiple types of data including data from initial clinical investigations/performance studies and data gathered by the manufacturer’s post-market surveillance system. To operationalise this new requirement, research is needed to help regulators develop common methodological frameworks (including common specifications) on the clinical evidence needed to demonstrate safety, performance and clinical benefit all along the life cycle of devices taking into account the type of device and clinical intended purpose.

Such methodological frameworks and standardised approaches are particularly needed for high-risk medical devices, e.g. implantable and class III medical devices, class C and D IVDs, medical device software (including AI enabled devices and next generation sequencing) and other highly innovative devices.

Validation of fluid-derived biomarkers for the prediction and prevention of brain disorders

Code: 28337 | Identifier Code: HORIZON-HLTH-2024-DISEASE-03-13-two-stage | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 26/04/2023 | End submission calls: 19/09/2023

Tackling high-burden for patients, under-researched medical conditions

Code: 28335 | Identifier Code: HORIZON-HLTH-2024-DISEASE-03-14-two-stage | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 26/04/2023 | End submission calls: 19/09/2023

A number of medical conditions fail to be recognized and/or correctly diagnosed in a significant proportion of patients. Consequently, they are undertreated and can often become a chronic burden to the patient. These medical conditions may be under-researched despite their high prevalence. This topic excludes rare diseases.

Comparative effectiveness research for healthcare interventions in areas of high public health need

Code: 28333 | Identifier Code: HORIZON-HLTH-2024-DISEASE-03-08-two-stage | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 26/04/2023 | End submission calls: 19/09/2023

The paediatric population, including children born preterm, has also its specific needs in specially adjusted therapeutics and early interventions to address emerging health and developmental problems. Similar to the elderly population, the paediatric population is often excluded from many clinical trials that generate the evidence base for healthcare interventions. Women, including pregnant women, are also often under-represented in clinical studies and access to quality healthcare is frequently inadequate. Other population groups with limited access to quality healthcare and/or under-representation in clinical studies include low-income groups, and refugees. Intersectionality within these groups also needs consideration.

Pandemic preparedness and response: Adaptive platform trials for pandemic preparedness

Code: 28329 | Identifier Code: HORIZON-HLTH-2024-DISEASE-03-11-two-stage | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 26/04/2023 | End submission calls: 19/09/2023

This topic aims to provide funding to adaptive clinical platform trials that may be implemented routinely outside of an epidemic or pandemic context, but that are designed to be ready for the timely assessment of novel diagnostics, therapeutics or vaccines in the face of an epidemic or pandemic.

Personalised prevention of non-communicable diseases - addressing areas of unmet needs using multiple data sources

Code: 28306 | Identifier Code: HORIZON-HLTH-2024-STAYHLTH-01-05-two-stage | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 30/03/2023 | End submission calls: 19/09/2023

Towards a holistic support to children and adolescents’ health and care provisions in an increasingly digital society

Code: 28282 | Identifier Code: HORIZON-HLTH-2024-STAYHLTH-01-02-two-stage | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 30/03/2023 | End submission calls: 19/09/2023

This topic aims at supporting activities that are enabling or contributing to one or several impacts of destination 1 “Staying healthy in a rapidly changing society”. To that end, proposals under this topic should aim for delivering results that are directed at, tailored towards and contributing to all of the following expected outcomes:

• Children, adolescents and their parents/carers are educated and empowered in prevention strategies involving personalised approaches and solutions (also through the use of digital tools) to manage, maintain and improve children’s and adolescents’ own health, physical activity, nutrition habits, leisure needs, mental and social well-being, in full respect of the privacy of individuals.
• Children and adolescents, including those from vulnerable contexts, monitor their health risks, adopt healthy lifestyles at home, at school and in the community and interact with their doctors and carers (receiving and providing feedback), also through the means of digitally enabled solutions, better health literacy, training and critical thinking.
• Thanks to better co-creation, training, digital and health literacy, children, adolescents, parents and carers across Europe access and use person-centred, widely available solutions for children and adolescents’ health, care and wellbeing, appropriate to a rapidly changing and increasingly digitalised society, also considering the risk of digital addiction.

Innovative non-animal human-based tools and strategies for biomedical research

Code: 28236 | Identifier Code: HORIZON-HLTH-2024-TOOL-05-06-two-stage | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 30/03/2023 | End submission calls: 19/09/2023

Proposals to be submitted under this call should develop and/or use tools and strategies that address critical areas of biomedical research where animal-models are currently used but are of limited translational value for investigation and development of prevention and treatment. Such advanced tools and strategies should aim at a better understanding of the pathogenesis of disorders that feature a high impact on public health and exhibit a high rate of animal use or severe animal suffering, and enable to develop biomedical concepts with increased translational value, thereby ultimately leading to improved disease prediction, prevention and treatment.

The role of environmental pollution in non-communicable diseases: air, noise and light and hazardous waste pollution

Code: 28198 | Identifier Code: HORIZON-HLTH-2024-ENVHLTH-02-06-two-stage | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 30/03/2023 | End submission calls: 19/09/2023

The European Green Deal set out by the European Commission recognises that man-made environmental pollution is an increasing threat for human health and wellbeing. Opinion polls show that climate change, air pollution, and waste are the three most important environmental issues that European citizens are concerned about.

Access to health and care services for people in vulnerable situations

Code: 28196 | Identifier Code: HORIZON-HLTH-2024-CARE-04-04-two-stage | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 30/03/2023 | End submission calls: 19/09/2023

Activities under this call should focus on groups that are in vulnerable situations from a social, financial or health perspective, or at risk of discrimination, such as migrants, Roma people, trans and intersex people, specific age and gender groups (that intersects with other aspects of vulnerability, such as elderly women), indigenous people, homeless people, people in poverty or at risk of poverty, people with disabilities or patients with complex conditions.

The Silver Deal - Person-centred health and care in European regions

Code: 27321 | Identifier Code: HORIZON-HLTH-2023-STAYHLTH-01-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

This topic aims to implement strategies and actions in line with the Green Paper on Ageing, the EU Long-term care report, the ‘Healthier Together’ – EU Non-Communicable Diseases Initiative, the new EU Care Strategy, which strive to address demographic change and enable better health and care for Europe’s growing ageing societies, as well as to harness the potential of the Silver Economy. NCD prevention is highly relevant to reduce the need for long-term care. New tools and integrated care models are needed, reinforcing primary, community- and home-based health and long-term care provision, through better early detection and management of diseases among older people in an increasingly ageing society and overburdened health and care systems.

Maintaining access to regular health and care services in case of cross-border emergencies

Code: 26907 | Identifier Code: HORIZON-HLTH-2023-CARE-04-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

It is timely to take stock and identify lessons for maintaining care delivery. The goal is to be better prepared for the multiple challenges faced by health and care systems during emergencies, and ensure that necessary access to regular health and care services can be maintained.

It is important to have the right tools for maintaining access to regular health and care services, while also accommodating the more urgent needs of migrants, for example.

Pandemic preparedness and response: Sustaining established coordination mechanisms for European adaptive platform trials and/or for cohort networks

Code: 26905 | Identifier Code: HORIZON-HLTH-2023-DISEASE-03-05 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

This topic aims at maintaining and strengthening existing strategic coordination mechanisms across adaptive platform trials and across cohort studies in Europe and beyond for avoiding redundancies, promoting complementarities and facilitating cooperation among EU-funded clinical research for infectious diseases. Proposals should strengthen the leading role of the EU in clinical research preparedness for future epidemics and pandemics, through ensuring coordination of the European adaptive platform trials and of the European cohort studies. The coordination mechanisms support the longer-term perspective of preparedness for future infectious disease epidemics and pandemics, where the networks enable the conduct of perpetual platform trials and of perpetual strategic cohorts with the in-built agility to pivot to emerging diseases when an epidemic strikes.

Novel approaches for palliative and end-of-life care for non-cancer patients

Code: 26903 | Identifier Code: HORIZON-HLTH-2023-DISEASE-03-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

The complexity of health conditions related to life-threatening and chronic diseases, acute and chronic pain, late or long-term side effects as consequences of diseases and also their treatments affect quality of life of patients and their families and pose an immense societal and economic burden. Palliative and end-of-life care approaches improve quality of life of patients and professional and family caregivers through the prevention and relief of suffering by means of early identification, assessment and treatment of pain and other factors such as physical, psychosocial and spiritual problems. Therefore, a need exists to strengthen the evidence base for available patient-centred effective interventions improving quality of life and outcomes of patients of all ages in the domains of palliative and end-of-life care.

Resilience and mental wellbeing of the health and care workforce

Code: 26899 | Identifier Code: HORIZON-HLTH-2023-CARE-04-02 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

A resilient workforce in the health and care sectors is essential for the sustainability and prosperity of our societies. This adds to the struggle of health and care systems to attract new people to their workforce, but also to maintain the ones already working. A combination of factors such as changes in work organisation, budgetary and administrative pressures faced by health and care systems, systemic shortages of health professionals, precarious working conditions, structural inequalities and leaps in technological innovation may leave health and care workers with feelings of helplessness, physical or mental vulnerability or moral injury.
Technological innovations (including digitisation, big data and artificial intelligence applications) provide opportunities for a more efficient provision of health and care services, and for lightening the workload of health and care workers.

Interventions in city environments to reduce risk of non-communicable disease (Global Alliance for Chronic Diseases - GACD)

Code: 26897 | Identifier Code: HORIZON-HLTH-2023-DISEASE-03-03 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

The topic is focused on implementation research with the potential to reduce the risks of NCDs in cities in LMICs and/or vulnerable populations in HICs. Proposals should focus on implementation science around evidence-based interventions that promote healthy behaviours, and that have the potential to profoundly reduce the risk of chronic diseases and multi-morbidity. The proposed implementation research must be focus on addressing NCD risk factors associated with city environments and related health inequities. In all cases, the selected study population(s) must live in cities, which may include informal settlements near urban centres, peri-urban environments, and city centres.

Pandemic preparedness and response: Understanding vaccine induced-immunity

Code: 26895 | Identifier Code: HORIZON-HLTH-2023-DISEASE-03-17 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

Vaccines are a critical component needed to bring infectious disease pandemics under control. The availability of effective vaccines that are able to induce a strong and durable immune response are critical to respond to health threats caused by infectious disease epidemics or pandemics. A proactive approach to understanding the factors that affect vaccine durability and strength is necessary to ensure development of effective vaccines for future infectious disease outbreaks.

European Partnership on Rare Diseases

Code: 26893 | Identifier Code: HORIZON-HLTH-2023-DISEASE-07-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 19/09/2023

The partnership should contribute to achieving the objectives of the Pharmaceutical Strategy for Europe, in terms of fulfilling unmet medical needs (e.g. for rare diseases with so called “orphan medicinal products”) and ensuring that the benefits of innovation reach patients in the EU.
The co-funded European Partnership on rare diseases should be implemented based on the priorities identified in the SRIA and through a joint programme of activities ranging from coordinating and funding transnational research to highly integrative and community-driven ‘in-house’ activities such as innovation strategies for the efficient exploitation of research results, EU clinical trial preparedness activities, optimisation of research infrastructures and resources, including networking, training and dissemination activities.

Health impacts of endocrine-disrupting chemicals: bridging science-policy gaps by addressing persistent scientific uncertainties

Code: 26891 | Identifier Code: HORIZON-HLTH-2023-ENVHLTH-02-03 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

Endocrine disrupting chemicals (EDCs) are of increasing importance in chemical regulations in the European Union. This approach would aim at, inter alia, minimising overall exposure of humans and the environment to endocrine disruptors, paying particular attention to exposures during important periods of development of an organism, such as foetal development and puberty, possibly integrating a life course approach, as well as accelerating the development of a thorough research basis for effective and forward-looking decision-making. This includes research for the further management of chemicals (including multi-constituent chemicals as well as chemical mixtures), the understanding of the mechanistic effects of endocrine disruptors and their dose-response relationships (including at the molecular and cellular level through the use of new approach methodologies, such as ‘multiomics’, cheminformatics, in vitro 2D and 3D models, in vivo models and computational approaches), and the collection, sharing, harmonisation and combination of robust data sources.

Development and harmonisation of methodologies for assessing digital health technologies in Europe

Code: 26889 | Identifier Code: HORIZON-HLTH-2023-IND-06-07 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

The proposals under this topic are expected to develop and harmonise methodologies for assessing digital health technologies (including mhealth apps and telehealth, as well as Artificial Intelligence powered health technologies) in order to facilitate assessment of their added value at individual, health system and society levels and facilitate the cross-border deployment of digital health services within the EU. Existing Health Technology Assessment (HTA) methodology is well developed for health technologies such as medicinal products, but also for some categories of medical devices; however digitalisation raises new methodological challenges to the standardisation of assessment criteria such as privacy, cybersecurity, data storage and handling, interoperability, usability etc. Also including aspects like learning curves, iterative development of innovations, variability between settings, determining optimal timing of evaluations in the development process (maturity) are not yet solved.

Towards structuring brain health research in Europe

Code: 26884 | Identifier Code: HORIZON-HLTH-2023-DISEASE-03-06 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

Member States and Associated Countries have agreed to step up their coordination in the area of brain research, which could take the form of a European partnership on Brain Health in the second Strategic Plan of Horizon Europe.

Evidence-based interventions for promotion of mental and physical health in changing working environments (post-pandemic workplaces)

Code: 26882 | Identifier Code: HORIZON-HLTH-2023-ENVHLTH-02-02 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

Mental health and ergonomic-related problems affect a significant number of EU workers. Musculoskeletal disorders (MSDs) are one of the most common work-related health problems in the EU and workers and managers commonly identify stress, depression and anxiety as serious psychosocial outcomes of workplace exposures. Changes in the organisation of work can bring flexibility that allows more people to enter the labour force, but may also lead to psychosocial problems.
Some workplaces have either become exclusively virtual or they have evolved into a ‘hybrid’ model (e.g. multilocational working, home office), some work tasks and processes performed virtually and others requiring physical presence. A significant number of jobs are performed at clients’ premises or require workers to commute long distances and/or cross borders regularly. Data on how these affect their mental/physical health and well-being is scarce.

Clinical trials of combined Advanced Therapy Medicinal Products (ATMPs)

Code: 26879 | Identifier Code: HORIZON-HLTH-2023-TOOL-05-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

The subjects of this topic are combined ATMPs (Advanced Therapy Medicinal Products). Such combined ATMPs are composed of an ATMP and one or more medical devices or one or more active implantable medical devices, and their cellular or tissue part must either contain viable cells or tissues, or non-viable cells or tissues liable for exerting the primary action on the human body.
Research should focus on advanced stages of clinical development with regulatory work on the Medical Device part completed and safety studies of the combination product in an advanced stage.

Better integration and use of health-related real-world and research data, including genomics, for improved clinical outcomes

Code: 26872 | Identifier Code: HORIZON-HLTH-2023-TOOL-05-04 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

This topic aims to support proposals focusing on the integration of health data from multiple sources (e.g. electronic health records, genomics, medical imaging, laboratory and diagnostic results, pathogen data, public health registries and other clinical research data) by linking real-world and clinical research data. The data integration should be exemplified in several use-cases, i.e. well-justified groups of diseases (excluding cancer), within and/or across medical domains, and pave the way towards improved health outcomes. At least one of those use cases should build on the use of whole genome sequence data.

Harnessing the potential of real-time data analysis and secure Point-of-Care computing for the benefit of person-centred health and care delivery

Code: 26866 | Identifier Code: HORIZON-HLTH-2023-TOOL-05-05 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

The proposals under this topic are expected to develop and test innovative tools, devices and systems for point-of-care applications, including but not limited to robotics, photonics, bio-sensing, artificial intelligence etc. The proposals should demonstrate advancement and integration of technologies from proof-of-concept to prototype demonstration in operational environment. Devices and systems should be designed, developed and tested vis-à-vis defined use cases, based on the appropriate involvement of clinicians and other stakeholders, ensuring they can be seamlessly integrated into existing digital infrastructures and clinical workflows. The use cases in care settings could include but are not limited to surgery workflows, Intensive Care Unit workflows and integration of remote patient monitoring into clinical workflows. Data quality, integration and interoperability, as well as issues of cybersecurity and data protection have to be addressed. Clinical studies should be an integral part of the work proposed, with developmental iteration steps and consultation of regulators included as appropriate. Establishing synergies with AI Testing and Experimentation Facilities, European Digital Innovation Hubs and other similar initiatives is encouraged. Proposals must include a short description of initial business plan as part of the exploitation activities.

Developing a Data Quality and Utility Label for the European Health Data Space

Code: 26864 | Identifier Code: HORIZON-HLTH-2023-TOOL-05-09 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

The European Health Data Space (EHDS) will provide a common EU framework for secondary use of health data such as research, innovation, regulatory purposes, policymaking and personalised medicine. It will enable data users to have access to large amounts of health data through health data access bodies empowered with the EHDS legal provisions to overcome existing limitations regarding the processing of health data for secondary uses. To support data users in the discovery and selection of datasets for their purposes, there is a growing need to develop a data quality and utility framework to articulate the characteristics and the potential usefulness of datasets. This framework will also support data holders in identifying and addressing areas of improvement which can, in turn, allow for wider and better use of these datasets. The proposed framework should take into account the various needs of data users whilst at the same time avoid becoming an excessive burden on data holders which will need to produce the data quality and utility label.

Environmentally sustainable and climate neutral health and care systems

Code: 26862 | Identifier Code: HORIZON-HLTH-2023-CARE-04-03 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

Health and care systems are undergoing structural changes, for example by strengthening primary care and community-based care, strengthening digitalisation and making sure patients are treated or cared for at the most efficient level. This offers the possibility to connect structural changes with an environmental transformation.
Research and innovation activities under this topic should be specific to health and care sectors. They should include cost studies when relevant (environmental impacts and benefits to be quantified through the life cycle thinking approach (e.g. LCA/SLCA), to be effectively implemented in line with the European Green Deal and the Zero Pollution Action Plan) and piloting research results onsite in hospitals or other care settings while generating accessible knowledge could be included.

European Partnership on Personalised Medicine

Code: 26860 | Identifier Code: HORIZON-HLTH-2023-CARE-08-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

The partnership should facilitate exchange of information and good practices among countries, provide robust guidance and tools, will network institutional stakeholders and involve regional ecosystems. It should stimulate service, policy and organisational innovations, as well as the integration of biomedical and technological innovations for the benefit of the European citizens and the European industry. The partnership should bring together a broad range of actors with a common vision of future personalised medicine. Through the objectives of Horizon Europe, the partnership should contribute to achieving the following European Commission priorities:

• Promoting our European way of life
• An economy that works for people
• A Europe fit for the digital age
• A European green deal

Pandemic preparedness and response: Broad spectrum anti-viral therapeutics for infectious diseases with epidemic potential

Code: 26858 | Identifier Code: HORIZON-HLTH-2023-DISEASE-03-04 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

Proposals under this topic should cover viruses for which there are no currently available effective therapeutics or for which the therapeutics available are sub-optimal, and are expected to incorporate state-of-the-art screening technology and innovative approaches to identify new targets for antiviral compound development. Emphasis should be put on the research and development of broad-spectrum antivirals, which may include repurposing of previously approved or in-pipeline drugs. Proposals could also include elucidation of mode-of-action for candidate anti-viral therapeutics.
Proposals should aim to diversify and accelerate the global therapeutic research and development pipeline for emerging and re-emerging viral infections, and to strengthen the current leading role of the EU in therapeutic research and development.

Pandemic preparedness and response: Immunogenicity of viral proteins of viruses with epidemic and pandemic potential

Code: 26856 | Identifier Code: HORIZON-HLTH-2023-DISEASE-03-18 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

Proposals under this topic should identify targets for optimal vaccine design for those pathogens where information on host-pathogen interaction and viral surface structures is already available. It is necessary to determine the extent of genetic variation with a view to develop vaccines with variant efficacy. In addition, it is necessary to develop animal and alternative models for the testing of vaccine candidates and for the kinetics, strength, breadth and persistence of the immune response. Proposals should focus on the following viruses: Hendra and Nipah Virus, Lassa virus, Crimean Congo haemorrhagic fever virus, Rift Valley fever virus, Ebola and Marburg virus, Dengue virus, Yellow Fever virus, Zika virus, West Nile fever virus and Chikungunya virus.

Planetary health: understanding the links between environmental degradation and health impacts

Code: 26854 | Identifier Code: HORIZON-HLTH-2023-ENVHLTH-02-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

Planetary health is a concept focused on the interdependencies between human health and the state of earth’s complex natural systems. A key focus is on understanding how the current trend of human-related environmental degradation can affect the health and well-being of current and future generations.
Applicants under this topic are invited to submit proposals providing actionable evidence for policymakers to take preventive actions to protect the human health and wellbeing by exploring the links between human health and environmental degradation in an integrated and comprehensive manner.

Expanding the European Electronic Health Record exchange Format to improve interoperability within the European Health Data Space

Code: 26852 | Identifier Code: HORIZON-HLTH-2023-IND-06-02 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

Electronic Health Record (EHR) interoperability has yet to become a reality in a number of use cases and health information domains. It is a complex, multi-dimensional challenge. EHRs across the Member States are diverse; so are languages, cultures, and practices in the health sector. Different technical specifications, technologies and clinical terminologies are used, involving a range of stakeholders, within and across care settings.

The Silver Deal - Person-centred health and care in European regions

Code: 26847 | Identifier Code: HORIZON-HLTH-2023-STAYHLTH-01-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

This topic aims to implement strategies and actions in line with the Green Paper on Ageing, the EU Long-term care report, the ‘Healthier Together’ – EU Non-Communicable Diseases Initiative, the new EU Care Strategy, which strive to address demographic change and enable better health and care for Europe’s growing ageing societies, as well as to harness the potential of the Silver Economy. NCD prevention is highly relevant to reduce the need for long-term care. New tools and integrated care models are needed, reinforcing primary, community- and home-based health and long-term care provision, through better early detection and management of diseases among older people in an increasingly ageing society and overburdened health and care systems.

Mapping the hurdles for the clinical applications of Advanced Therapy Medicinal Products (ATMPs)

Code: 26845 | Identifier Code: HORIZON-HLTH-2023-IND-06-05 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

New pioneering treatments called Advanced Therapy Medicinal Products (ATMPs), including cell and gene therapies, have the potential to bring new cures to patients affected by diseases with limited or no available treatments. However, several hurdles impede or slow down the access of ATMPs to patients in the EU and Associated Countries. These include e.g. regulatory challenges, underlying scientific uncertainties, differences in assessing the values of ATMPs by the various Health Technology Agencies (HTA), difficulties to perform randomised-controlled clinical trials or to obtain long-term safety and effectiveness data, the lack of harmonised approaches to the reimbursement of the high upfront costs by health systems, manufacturing processes, etc.

Integrated, multi-scale computational models of patient patho-physiology (‘virtual twins’) for personalised disease management

Code: 26842 | Identifier Code: HORIZON-HLTH-2023-TOOL-05-03 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

This topic will contribute to the consolidation of existing virtual twin models and support research to move towards a more integrated human virtual twin, with the aim to accelerate translational research towards cost-effective development of new health technologies. Furthermore, ‘virtual twin’ patient models hold the potential of transforming clinical processes and healthcare with longitudinal monitoring, making personalised medicine, disease prevention and individualised patient management a reality.

Supporting the uptake of innovative Health Technology Assessment (HTA) methodology and advancing HTA expertise across EU

Code: 26839 | Identifier Code: HORIZON-HLTH-2023-IND-06-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

HTA bodies have the responsibility to assess the added value of new health technologies and advise on its reimbursement and use within a healthcare system. Due to the rapid pace at which technology advance and in order to support decision making in an appropriate manner, HTA experts have to adapt/revise regularly their methodology. Whilst EU-funded projects in the field of HTA have addressed some of the research needs of the HTA bodies (e.g. methods of analysis, use of real-world data, use of patient reported outcomes), translation of their results/recommendations into HTA work remains limited.
Τhis action could represent an excellent opportunity for both those generating and those using the evidence to come together and discuss the key HTA methodological issues.
Τhe Coordination Group on HTA will have to adopt methodological guidelines for joint HTA work (e.g. joint clinical assessments, joint scientific consultation).

Relationship between infections and non-communicable diseases

Code: 26836 | Identifier Code: HORIZON-HLTH-2023-DISEASE-03-07 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

Proposals under this topic are expected to elucidate and provide a better understanding of causative links between infections and non-communicable diseases onsets, and/or the impact of infections on the exacerbation of existing NCDs or vice versa, in children and/or adults. The analysis of genetics, immune status, immune or inflammatory responses, microbiome, lifestyle and/or other relevant factors (e.g. differences in age, sex/gender, vaccination status, ethnicity) should be integrated to get information for prevention, early diagnosis, risk factors, and to better understand causative links as well as the progression of those non-communicable diseases.

Global coordination of exposome research

Code: 26834 | Identifier Code: HORIZON-HLTH-2023-ENVHLTH-02-04 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

The concept of the exposome refers to the totality of environmental exposures from conception onwards, including its external (e.g. diet, lifestyle, occupational and environmental factors) and internal components (e.g. epigenomics, metabolomics).Developing a comprehensive Human Exposome Project would present a fundamental shift in looking at health, by moving research away from ‘one exposure, one disease’ understanding to a more complex picture upon which to build solid, cost-effective preventive actions and policies.
The network of projects aims to study the combination of exposures to pollutants and other stressors, across different life stages and socio-economic conditions, via a number of exposure vehicles such as consumption patterns, lifestyle and working and living environment, and their collective effect on human health.

Modelling and simulation to address regulatory needs in the development of orphan and paediatric medicines

Code: 26832 | Identifier Code: HORIZON-HLTH-2023-IND-06-04 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

The topic will support research and innovation activities focusing on the development of diverse modelling and simulation methods, as tools for addressing some of the regulatory needs in the clinical development cycle of new orphan and paediatric medicinal products. The topic is not intended to implement new preclinical/clinical studies but to use the existing knowledge/data for assessing and optimising the performance of mature in-silico models in the regulatory context with the goal of improving the clinical trial designs for small populations. Availability of the relevant data to address the requirements of the topic is an indispensable condition that must be demonstrated at the proposal submission.
SME(s) participation is encouraged with the aim to strengthen their scientific and technological basis.

Pandemic preparedness and response: In vitro diagnostic devices to tackle cross-border health threats

Code: 26822 | Identifier Code: HORIZON-HLTH-2023-TOOL-05-08 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2023 | End submission calls: 13/04/2023

Proposals under this topic should aim for delivering results that are directed, tailored towards and contributing to all of the following expected outcomes:

• The scientific and clinical communities, including health care providers and payers, as well as regulators, health systems and patients benefit from innovative diagnostic solutions that are better suited to tackle cross-border health threats.
• The scientific and clinical communities have access to novel and improved methodologies for detection of pathogens with pandemic potential in humans and for timely discovery of other health threats, such as chemical, radiological and nuclear threats, including considerations on detection in animals and environmental conditions.
• A diverse and robust pipeline of in vitro diagnostics is available, increasing options for clinical deployment in case of an epidemic or pandemic.

Pandemic preparedness

Code: 17502 | Identifier Code: HORIZON-HLTH-2022-DISEASE-07-02 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2022 | End submission calls: 21/04/2022

Proposals under this topic should aim for delivering results that are directed, tailored towards and contributing to some of the following expected outcomes:

• The scientific community has better understanding of the biology of the pathogens (virus, bacteria etc.), its transmission, its interaction with humans, animals and plants, in particular in view of emerging threats to human health, such as infectious diseases and anti-microbial resistance.
• Health care providers and practitioners have access to and use appropriate medical countermeasures, e.g. vaccines, diagnostics, therapeutics and digital solutions.
• Health authorities have the evidence-base and tools for better public health measures.

Non-communicable diseases risk reduction in adolescence and youth (Global Alliance for Chronic Diseases - GACD)

Code: 17500 | Identifier Code: HORIZON-HLTH-2022-DISEASE-07-03 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2022 | End submission calls: 21/04/2022

The topic is focused on implementation research about common risk prevention interventions targeting adolescents and youth to reduce the impact of non-communicable diseases (NCDs) in low- and middle-income countries (LMICs) and vulnerable populations in high-income countries (HICs). Proposals should focus on implementation science around evidence-based interventions that promote healthy behaviours, and that have the potential to profoundly reduce the risk of chronic diseases and multimorbidity.

Support for the functioning of the Global Research Collaboration for Infectious Disease Preparedness (GloPID-R)

Code: 17498 | Identifier Code: HORIZON-HLTH-2022-DISEASE-07-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 12/01/2022 | End submission calls: 21/04/2022

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 3 “Tackling diseases and reducing disease burden”.

Methods for assessing health-related costs of environmental stressors

Code: 15920 | Identifier Code: HORIZON-HLTH-2022-ENVHLTH-04-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 06/10/2021 | End submission calls: 21/04/2022

Policy-makers face challenges when devising pollution mitigation measures and having to assess the health costs emerging from life-long exposures to environmental stressors or the benefits from clean environments. Proposed research activities should mainly aim to improve the calculation of the socio-economic costs (and/or benefits) of health impacts during the life-course associated to environmental stressors, or combinations of these, advance methodological approaches and foster their acceptance as common good practice.

New pricing and payment models for cost-effective and affordable health innovations

Code: 15918 | Identifier Code: HORIZON-HLTH-2022-IND-13-03 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 06/10/2021 | End submission calls: 21/04/2022

Applicants for this prosposal are requested to propose new value-based pricing and reimbursement models that can help ensure equitable access to effective, efficient, affordable, and sustainable health technologies, including medicines, while supporting innovation and industrial competitiveness.
The proposals should not be limited to the study of cost-effectiveness analyses and thresholds in decision-making. They should also address long term intended and unintended consequences of pricing and reimbursement decisions.

Scaling up multi-party computation, data anonymisation techniques, and synthetic data generation

Code: 15913 | Identifier Code: HORIZON-HLTH-2022-IND-13-02 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 06/10/2021 | End submission calls: 21/04/2022

It is essential to speed up and facilitate innovations in the field of data-driven tools and services for wellbeing, prevention, diagnosis, treatment and follow-up of care, among others. Therefore, the proposals are expected to scale up multi-party computation, data anonymisation techniques and synthetic data generation. To ensure privacy, the data analytics should be conducted in a distributed way among processors that grant third parties access to analysis outcomes but not to the underlying data. The developers should have access to distributed testing data sources and cloud and computing resources at large scale, with a view to improving the speed and robustness of multi-party computation solutions for innovators. The aim is to allow secure GDPR-compliant data processing for research, and clinical purposes.

Enhancing cybersecurity of connected medical devices

Code: 15910 | Identifier Code: HORIZON-HLTH-2022-IND-13-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 06/10/2021 | End submission calls: 21/04/2022

The proposals are expected to help strengthening cybersecurity maintaining the performance of medical devices while preserving or enhancing safety, security and data confidentiality, integrity and availability. The applicants should tackle the cybersecurity issue of connected medical devices and in vitro diagnostic medical devices, in particular those that are connected to the internet, allow remote access to data and exchange private or proprietary data.

Pre-commercial research and innovation procurement (PCP) for building the resilience of health care systems in the context of recovery

Code: 15905 | Identifier Code: HORIZON-HLTH-2022-CARE-08-02 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 06/10/2021 | End submission calls: 21/04/2022

This topic prioritises areas of health care such as health promotion, preparedness, prevention, surveillance and rapid response to cross-border health threats.
Pre-commercial procurement (PCP) can boost innovation in health care systems, while building the capacity of providers and increasing resilience and preparedness in the context of cross-border public health emergencies. Through the competitive development of a range of breakthrough innovations for a concrete health care challenge, PCP can strengthen the security of the supply chain in the health care sector.

Boosting mental health in Europe in times of change

Code: 15827 | Identifier Code: HORIZON-HLTH-2022-STAYHLTH-01-01-two-stage | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 06/10/2021 | End submission calls: 01/02/2022

Against the backdrop of a transforming Europe and in the midst of a global pandemic, the EU is committed to lead the transition to a healthier planet and a new digital world. The health and wellbeing of its citizens is a prerequisite to achieve this aspiration.

Trustworthy artificial intelligence (AI) tools to predict the risk of chronic non-communicable diseases and/or their progression

Code: 15824 | Identifier Code: HORIZON-HLTH-2022-STAYHLTH-01-04-two-stage | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 06/10/2021 | End submission calls: 01/02/2022

This topic will support multidisciplinary research, build on broad stakeholder engagement and support proposals developing novel robust and trustworthy AI tools to enable timely personalised prevention approaches for chronic non-communicable diseases/disorders.

Prevention of obesity throughout the life course

Code: 15822 | Identifier Code: HORIZON-HLTH-2022-STAYHLTH-01-05-two-stage | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 06/10/2021 | End submission calls: 01/02/2022

Increased efforts in research and innovation are critical for developing and testing the impact of tools, initiatives, interventions, strategies, programmes, policies and their implementation to prevent overweight/obesity. The use of best practices, harmonisation guidelines and/or standard operating procedures, developed at various levels (from local to national) in the EU and beyond, will be the foundation for new research.

Personalised blueprint of chronic inflammation in health-to-disease transition

Code: 15816 | Identifier Code: HORIZON-HLTH-2022-STAYHLTH-02-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 06/10/2021 | End submission calls: 21/04/2022

Personalised approaches for disease prevention seek to determine the predisposition to disease and deliver timely and targeted prevention measures. Understanding the risk factors that trigger the health-to-disease transition is essential for delivering personalized prevention measures or reducing the burden of chronic diseases.
The later in combination with the person’s genotype, phenotype, medical history, nutritional and well-being status, life-style and/or occupational/environmental/life stressors is likely to be involved in driving the health-to-disease transition, leading to the onset of chronic diseases.

Optimising effectiveness in patients of existing prescription drugs for major diseases (except cancer) with the use of biomarkers

Code: 15814 | Identifier Code: HORIZON-HLTH-2022-TOOL-11-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 06/10/2021 | End submission calls: 21/04/2022

Proposals under this topic should aim for delivering results that are directed, tailored and contributing to all of the following expected outcomes:
a) Diagnostics industries move towards market approval for companion diagnostics.
b) Regulatory authorities approve companion diagnostics and make recommendations for the prescription of existing drugs.
c) Health care providers use biomarkers with existing pharmaceuticals to treat more efficiently and cost-effectively patients, with less adverse effects.

New methods for the effective use of real-world data and/or synthetic data in regulatory decision-making and/or in health technology assessment

Code: 15812 | Identifier Code: HORIZON-HLTH-2022-TOOL-11-02 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 06/10/2021 | End submission calls: 21/04/2022

With the emerging use of real-world data (RWD) and synthetic data by the pharmaceutical industry and medical devices industry, regulators and HTA bodies need to perform targeted validation of claims through independent analysis. The principal aim of this topic is to address the data needs of health regulatory bodies and HTA bodies across the EU, as outlined in the recently published “HMA-EMA Joint Big Data Taskforce Phase II report: ‘Evolving Data-Driven Regulation’’ and its associated DARWIN (Data Analysis and Real World Interrogation Network) project.

Computational models for new patient stratification strategies

Code: 15808 | Identifier Code: HORIZON-HLTH-2022-TOOL-12-01-two-stage | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 06/10/2021 | End submission calls: 01/02/2022

In the era of big and complex data, the challenge remains to make sense of the huge amount of health care research data. Computational approaches hold great potential to enable superior patient stratification strategies to the established clinical practice, which in turn are a prerequisite for the development of effective personalised medicine approaches.
The topic covers different stages in the continuum of the innovation path (i.e. translational, pre-clinical, clinical research, validation in the clinical and real-world setting, etc.), as relevant to the objectives of the proposals. The topic will support the development of the computational models driven by the end users’ needs.

Setting up a European Smart Health Innovation Hub

Code: 15803 | Identifier Code: HORIZON-HLTH-2022-IND-13-04 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 06/10/2021 | End submission calls: 21/04/2022

Building on the recommendations from the report of the Strategic Forum for Important Projects of Common European Interest, coordination and support is needed to:
i) create a pan-European operational network as a mechanism (a European Smart Health Innovation Hub) that can assess and promote Smart Health initiatives; ii) stimulate the demand-side and the uptake of Smart Health products and services; and iii) support the development of Smart Health products and services.

Setting up a European Electronic Health Record Exchange Format (EEHRxF) Ecosystem

Code: 15800 | Identifier Code: HORIZON-HLTH-2022-IND-13-05 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 06/10/2021 | End submission calls: 21/04/2022

Interoperability of Electronic Health Record is key for the exchange and the portability of health data in view of better health outcomes and treatments. There is a need to continue supporting the uptake of new use cases (i.e. laboratory results, medical imaging and reports, and hospital discharge reports) and take on board possible new requirements, and ultimately to bring together policy actors and stakeholders.

Pre-clinical development of the next generation of immunotherapies for diseases or disorders with unmet medical needs

Code: 15798 | Identifier Code: HORIZON-HLTH-2022-DISEASE-06-02-two-stage | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 06/10/2021 | End submission calls: 01/02/2022

The next generation of immunotherapies are needed in order to improve and diversify the capabilities of health care for several communicable and non-communicable diseases that cannot be effectively tackled with the currently available treatments.
Proposals should build on existing knowledge in the field, when available, in order to save time and to avoid spilling resources, and could build on the knowledge of the interaction between the immune system (innate and adaptive arms) and the microbiota, or take advantage of key enabling technologies such as biotechnology and nanotechnology, advanced manufacturing, imaging, 5G, internet of things, artificial intelligence and existing databases.

Vaccines 2.0 - developing the next generation of vaccines

Code: 15788 | Identifier Code: HORIZON-HLTH-2022-DISEASE-06-03-two-stage | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 06/10/2021 | End submission calls: 01/02/2022

Proposals should aim to diversify and accelerate the global vaccine research and development pipeline, and to strengthen the current leading role of the EU in vaccine research and development. Proposals should cover those pathogens, which still lack vaccines of sufficient efficacy, but where earlier efforts have already produced promising vaccine candidates.

Development of new effective therapies for rare diseases

Code: 15786 | Identifier Code: HORIZON-HLTH-2022-DISEASE-06-04-two-stage | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 06/10/2021 | End submission calls: 01/02/2022

Τhe number of available therapies for rare diseases remains low, as fewer than 6% of rare diseases have an approved treatment option. Τhere is an urgent unmet medical need for the development of therapies for rare diseases, where there is still no approved therapeutic option available. Therefore, proposals should aim to develop therapies for rare diseases with no approved therapeutic option.

Better financing models for health systems

Code: 15784 | Identifier Code: HORIZON-HLTH-2022-CARE-08-04 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 06/10/2021 | End submission calls: 21/04/2022

Proposals under this topic should aim for delivering results that are contributing to some of the following expected outcomes:

a) Decision and policymakers in the field of health care avail of new approaches to financial planning and financing mechanisms that provide flexibility to stretched health budgets.
b) Decision and policymakers in the field of health care apply cost-effective spending strategies based on the optimisation of the use of resources, while maintaining or improving health outcomes in an equitable way;
c) Decision and policymakers in the field of health care access tools that enable them to better remunerate, contract and incentivise health care professionals and providers;
d) Decision and policymakers in the field of health care take evidence-based and socially equitable health care financial decisions.

European partnership on transforming health and care systems

Code: 15781 | Identifier Code: HORIZON-HLTH-2022-CARE-10-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 06/10/2021 | End submission calls: 21/04/2022

The creation of a research and innovation (R&I) partnership with a focus on health and care systems’ transformation represents a unique strategic opportunity to bring together stakeholders, create synergies, coordinate R&I actions, facilitate the digitisation of health and care services and support the transformation of health and care systems with innovative solutions driven by knowledge and evidence.

Public procurement of innovative solutions (PPI) for building the resilience of health care systems in the context of recovery

Code: 15770 | Identifier Code: HORIZON-HLTH-2022-CARE-08-03 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 06/10/2021 | End submission calls: 21/04/2022

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 4 “Ensuring access to innovative, sustainable and high-quality health care”.
This topic prioritises areas of health care such as health promotion, preparedness, prevention, surveillance and rapid response to cross-border health threats.

Promoting a trusted mHealth label in Europe: uptake of technical specifications for quality and reliability of health and wellness apps

Code: 11038 | Identifier Code: HORIZON-HLTH-2021-IND-07-03 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

Europe is experiencing a fast growing market for health and wellness apps. At the same time, concerns about the quality and reliability of apps have risen. The objective of the technical specification is to define quality and reliability criteria, which support app developers to design and users of apps to select better apps.

Development, procurement and responsible management of new antimicrobials

Code: 11036 | Identifier Code: HORIZON-HLTH-2021-IND-07-02 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

The aim of this topic is to prepare for the establishment of a pull incentive for new antimicrobials where there is an unmet public health need and a market failure.

Green pharmaceuticals

Code: 11032 | Identifier Code: HORIZON-HLTH-2021-IND-07-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

The EU needs to address the increasing problem of environmental pollution due to pharmaceuticals throughout their life cycle. This topic is part of an EU strategic approach to pharmaceuticals in the environment and the Pharmaceutical strategy for Europe called for diversifying and secure supply chains and environmentally sustainable pharmaceuticals.
The purpose of this topic is twofold.

Innovative tools for use and re-use of health data (in particular of electronic health records and/or patient registries)

Code: 11025 | Identifier Code: HORIZON-HLTH-2021-TOOL-06-03 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

Health data exists in many forms and multiple fragmented repositories; there is still significant room for improvement in the way both structured and unstructured health data is stored, analysed and interpreted. Sharing and analysing data from multiple countries in a safe and legally compliant manner (in particular with regard to personal data protection) remains a challenge. Advances in AI and machine learning, however, have the potential to transform the way clinicians, providers and researchers use unstructured data.

Next generation advanced therapies to treat highly prevalent and high burden diseases with unmet medical needs

Code: 11020 | Identifier Code: HORIZON-HLTH-2021-TOOL-06-02 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

The recent development of advanced therapies has been hampered by the lack of robust research on certain key parameters e.g. safety, upscaling, immunity, potency assays, cost-effectiveness, and early on in development. This topic aims to ensure that the next wave of advanced therapies, based on either pluripotent stem cells, gene editing or RNA, are established in a timely fashion and in accordance with the appropriate regulatory standards for further clinical testing.

Smart medical devices and their surgical implantation for use in resource-constrained settings

Code: 11016 | Identifier Code: HORIZON-HLTH-2021-TOOL-06-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

Smart” technologies, i.e. micro-electronic sensor/actuator systems provide novel functionalities to surgically-implanted active medical devices.  There is a strong need for high-quality, affordable surgical interventions for implanting “smart” active medical devices suitable for resource-limited or -constrained clinical settings. 

Health care innovation procurement network

Code: 11004 | Identifier Code: HORIZON-HLTH-2021-CARE-05-04 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

This call aims to support the creation of a network of public and private procurers that are responsible for deploying health care innovations across the EU, in order to identify potential areas of interest for innovation procurement.

Data-driven decision-support tools for better health care delivery and policy-making with a focus on cancer

Code: 11000 | Identifier Code: HORIZON-HLTH-2021-CARE-05-02 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

This call topic will contribute to Europe’s Beating Cancer Plan activities and other relevant initiatives such as the European Cancer Information System. For this reason, proposals must focus on one or more phases of the cycle of the disease, starting from prevention and early diagnosis to treatment and quality of life of patients and survivors. In this topic, research and innovation actions should aim at optimising and/or transforming health care delivery decision-making processes, supporting policy-making, and/or empowering citizens and cancer patients.

Enhancing quality of care and patient safety

Code: 10998 | Identifier Code: HORIZON-HLTH-2021-CARE-05-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

Patient safety remains an issue of increasing concern for EU health systems. Overall, the most common types of in-hospital adverse effects are operative/surgical related, medication or drug related, and health care associated infections, half of them being preventable. Ιt is necessary to develop and implement coherent quality improvement and patient safety strategies in Europe. Harmonisation and standardisation of health care processes along the continuum of care contribute to improve quality and safety of health services, minimise the risk of errors and at the same time ensure the quality and comparability of health data. 

Building a European partnership for pandemic preparedness

Code: 10996 | Identifier Code: HORIZON-HLTH-2021-DISEASE-04-06 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

The COVID-19 pandemic illustrated how unilateral research initiatives may lead to a fragmented research landscape, with substantial room for efficiency gains in the development of the highly needed evidence to guide policy actions when facing an emergency. The expected future European partnership for pandemic preparedness should aim to improve the EU’s preparedness to predict and respond to emerging infectious health threats by better coordinating funding for research and innovation at EU, national (and regional) level towards common objectives and an agreed Strategic Research and Innovation Agenda.

A roadmap towards the creation of the European partnership on One Health antimicrobial resistance (OH AMR)

Code: 10975 | Identifier Code: HORIZON-HLTH-2021-DISEASE-04-05 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

The increasing levels of AMR present a major threat to human health with serious consequences also to animal and environmental health. Tackling AMR in bacteria, fungi, viruses and parasites requires a strong and coordinated response to protect citizens in Europe and beyond, as indicated in the European One Health Action Plan against AMR. This action plan provides the framework within which actions should be taken against this threat. It is recognised that combatting AMR requires a One Health approach, recognizing that human and animal health and the environment are interconnected. The challenge in the current situation is that the AMR research and innovation landscape is still too fragmented addressing human health, animal health, feed, food safety and environment in silos, and it is also fragmented across Member States. Therefore, there is the need to move towards the integration of the various disciplines to overcome this fragmentation, thus tackling the problem of AMR with a comprehensive One Health approach bringing the diverse actors together.

Personalised medicine and infectious diseases: understanding the individual host response to viruses (e.g. SARS-CoV-2)

Code: 10957 | Identifier Code: HORIZON-HLTH-2021-DISEASE-04-07 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

Proposals are expected to characterize the host response and host-pathogen interaction to a virus (or viruses) at the level of genetic patterns, physiological mechanisms and molecular pathways involving different organs and systems to identify factors that predispose to different clinical symptoms, different progression of the viral disease and different clinical outcomes. The study should include patient follow-up to identify conditions (including long-term ones) that may appear after the patient has recovered from the viral disease.

Clinical validation of artificial intelligence (AI) solutions for treatment and care

Code: 10955 | Identifier Code: HORIZON-HLTH-2021-DISEASE-04-04 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

Applying trustworthy-AI in healthcare contexts generate a multitude of benefits, including more effective disease management by optimised personalised treatments and assessment of health outcomes. Based on existing (pre)clinical evidence, proposals should focus on implementing clinical studies to validate AI-based solutions comparing their benefits versus standard-of-care treatments in non-communicable diseases. Proposals should pay special attention to the usability, performance and safety of the AI-based solutions developed, and above all to their clinical evaluation and (cost-)effectiveness in view of their inclusion into current clinical guidelines for personalised treatments following current EU regulatory framework.

Innovative approaches to enhance poverty-related diseases research in sub-Saharan Africa

Code: 10953 | Identifier Code: HORIZON-HLTH-2021-DISEASE-04-03 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

The European and Developing Countries Clinical Trials Partnership (EDCTP) has established itself as the focal point of cooperation in clinical research on infectious disease between the EU and sub-Saharan Africa. Τhere is a need to further support research on the major infectious disease threats facing sub-Saharan Africa. Despite large-scale investments in product development for poverty-related infectious diseases (PRDs), progress in achieving public health gain is slow, while sub-Saharan Africa bears the highest burden of these diseases. There is a need to support product development and to encourage the use of new, innovative approaches and emerging technologies in sub-Saharan Africa to achieve rapid progress and impact. 

Building a European innovation platform for the repurposing of medicinal products

Code: 10950 | Identifier Code: HORIZON-HLTH-2021-DISEASE-04-02 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

Development of therapeutics is a lengthy process that requires a large amount of efforts, time and financial resources. It is often burdened by delays and barriers that account for an average of almost 15 years until a promising candidate molecule becomes an approved medicine. It is therefore of paramount importance to define strategies that facilitate the reduction of timeframes, decrease costs and improve the success rate of this complex and lengthy process.

Improved supportive, palliative, survivorship and end-of-life care of cancer patients

Code: 10948 | Identifier Code: HORIZON-HLTH-2021-DISEASE-04-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

The complexity of health conditions related to cancer and late or long-term side effects as consequences of its treatments affect the quality of life of cancer patients and their families and pose a significant societal and economic burden. Τhere is a need to strengthen the evidence base for patient-centred, effective interventions improving the quality of life and outcomes of cancer patients and cancer survivors of all ages in the domains of supportive, palliative, survivorship and end-of-life care.

European partnership for the assessment of risks from chemicals (PARC)

Code: 10940 | Identifier Code: HORIZON-HLTH-2021-ENVHLTH-03-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

Chemicals risk assessors and managers are faced with data and knowledge gaps and lack of tools and methods, to speed up and prioritise risk assessments and capture risks from existing and emerging substances across regulatory domains. To enable risk assessors and risk managers to respond to current and future challenges, the Partnership should stimulate research and innovation in chemicals risk assessment by developing a collaborative network with public research entities.

Health impacts of climate change, costs and benefits of action and inaction

Code: 10910 | Identifier Code: HORIZON-HLTH-2021-ENVHLTH-02-03 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

The aim of this topic is the identification, monitoring and quantification of direct and indirect impacts on human health, including in occupational settings, and related risk factors correlated to climate change, especially in vulnerable population groups such as children or in groups at risk such as workers. Innovative surveillance tools are further required to ensure a timely response to emerging threats, to feed and strengthen early warning systems, and to enable the design, monitoring and evaluation of interventions. This may include mathematical modelling with big data and artificial intelligence (AI), remote sensing, citizen science and biomarkers of exposure or virulence.

Indoor air quality and health

Code: 10906 | Identifier Code: HORIZON-HLTH-2021-ENVHLTH-02-02 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

Air quality is primarily monitored in outdoor locations, often for regulatory targets compliance purposes. Ιmproving outdoor air quality leads to general improvements of indoor air quality as well, certain sources of air pollution not covered by ambient air quality standards can dominate in some indoor environments. In addition to identifying determinants for indoor air quality, it is important to assess their health impacts in the levels reached indoors to facilitate setting of purposeful indoor air quality standards. This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 2 ‘Living and working in a health-promoting environment’.

Exposure to electromagnetic fields (EMF) and health

Code: 10904 | Identifier Code: HORIZON-HLTH-2021-ENVHLTH-02-01 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

There has been an exponential increase in the use of wireless personal communication devices (new generation radio-communication networks, e.g. 5G) and this has resulted in an increase in man-made electromagnetic radiation in our surroundings. Due to this, the International Commission on Non-Ionizing Radiation Protection prepared guidelines for limiting exposure to electric, magnetic and electromagnetic fields. Nevertheless, there is some concern over the possible impact on health and safety from potentially higher exposure to EMF. 
While digitalisation presents new opportunities, e.g. distance monitoring of air and water pollution and health outcomes, it also presents potential health risks. Europe needs a digital sector that puts sustainability at its heart: when deploying new technologies, the potential risks related to human health should also be assessed.

Mobilising a network of National Contact Points (NCPs) for the Health Cluster

Code: 10895 | Identifier Code: HORIZON-HLTH-2021-STAYHLTH-01-05 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

Proposals should aim to facilitate trans-national co-operation between National Contact Points (NCPs) with a view to identifying and sharing good practices and raising the general standard of support to programme applicants.

A roadmap for personalised prevention

Code: 10893 | Identifier Code: HORIZON-HLTH-2021-STAYHLTH-01-04 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

The progress in medicine over the past decades has been impressive. Additionally, personalised prevention, holds many promises and would allow a paradigm shift in the provision and management of health care if efforts are co-ordinated and concentrated at the European and global levels. However, more could be achieved while identifying individuals at higher risk of developing a particular condition early on and before symptoms occur. Specifically, more insight is needed on the underlying human biology, taking stock of the rich data accumulated from the biomedical sciences.

Healthy Citizens 2.0 - Supporting digital empowerment and health literacy of citizens

Code: 10884 | Identifier Code: HORIZON-HLTH-2021-STAYHLTH-01-03 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

There is a growing body of evidence demonstrating the value of digital health interventions and solutions for health promotion, disease prevention and treatment. However, in parallel, it is vital to ensure that online-based patient-centred programmes do not leave behind the very people they are primarily designed to empower. Moreover, citizen’s digital health literacy is essential for the successful transformation of health care systems.

Towards a molecular and neurobiological understanding of mental health and mental illness for the benefit of citizens and patients

Code: 10882 | Identifier Code: HORIZON-HLTH-2021-STAYHLTH-01-02 | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/06/2021 | End submission calls: 21/09/2021

Mental illnesses represent a huge and growing burden for Europe, both at individual and societal level. There is a lack of evidence base on the optimal use of different pharmacological and non-pharmacological prevention strategies. A deeper molecular and neurobiological understanding of the interplay between genetic, epigenetic and environmental risk and resilience factors, including neural circuit alterations, is critical for the development of objective biomarkers and evidence-based interventions that will significantly improve mental health outcomes.

Vaccines & therapeutic clinical trials to boost COVID-19 prevention and treatment

Code: 3679 | Identifier Code: HORIZON-HLTH-2021-CORONA-01-01   | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 13/04/2021 | End submission calls: 06/05/2021

Proposals submitted under this expression of interest should aim to further develop promising therapeutic or prophylactic candidates against SARS-CoV-2/COVID-19.

Cohorts united against COVID-19 variants of concern

Code: 3682 | Identifier Code: HORIZON-HLTH-2021-CORONA-01-02   | Programme name: Health (Cluster 1) (2021-2027) | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 13/04/2021 | End submission calls: 06/05/2021

Proposals submitted under this Call are expected to build on existing large-scale, multi-centre, regional or international cohorts worldwide and/or establish new ones linked to those. These cohorts should aim to rapidly advance the knowledge on SARS-CoV-2 and its emerging variants of concern, with the aim of developing evidence-based strategic and robust recommendations for the effective control and prevention of COVID-19 infection.