Proposals should consider all of the following activities:

• Systematic review and exploitation of latest evidence of exposure-response functions and causation resulting from published medical and scientific research accumulated data from the past 10-20 years, including results published based on EU-funded research projects;
• Identification of data gaps as regards environment and health risk factors and health-related tangible and intangible costs and recommendations on priorities for new data collections;
• Advancement of methodological rigor and consistency in accounting for morbidity and mortality, disabilities, linking valuation of statistical life and/or life-years with quality adjustments within a unified framework, based on the most recent data available and adapted to the needs and circumstances in Europe;
• Application of experimental approaches addressing the potential link of quality of life and the burden of disease indicators with more integrative impact indicators (e.g. reflecting subjective well-being, health, work-life balance, education, housing, etc.) and identification of how national contexts can impact on health-related costs of the same environmental and occupational exposure;
• Enhancement of the understanding of the role of discounting and other methods for weighing present and future costs and benefits;
• Development of innovative tools, methods and models, and associated guidelines for health impact assessments and related cost-benefit analysis;
• Consultation of experts and stakeholders on tools, models, methods and assessments developed towards a shared agreement of these;
• Development of case studies involving public authorities comparing the costs of action and non-action in at least three EU or associated countries;
• Delivery of FAIR data and a user-friendly access to an open knowledge base including results, methodologies and data appropriate for use in public policies and budget allocations.