Proposals should address all of the following:

• Based on weaknesses, gaps and possibilities for further development of existing screening and early detection methods and technologies cancer screening and detection methodologies. This includes ‘integrated diagnostics’ based on, for example, imaging, tissue, fluid or exhaled breath gas biomarkers, and agile screening methodologies including digital technologies (such as self-sampling, mobile screening units, digital apps or smart wearables, sensors, telemedicine and remote monitoring technologies combined with sophisticated data analytics tools), duly considering digital and health literacy of people.
• Proposals should assess the potential uptake of these methods and technologies in national health systems, clearly identify the target population and consider implementation needs. Applicants should also consider aspects of effectiveness, affordability and accessibility when proposing solutions, particularly to enhance participation of the target population.
• Proposals should consider the use of living labs or other implementation research models that use open knowledge and (social) innovation systems and support end-user engagement.
• The influence of age and early-life factors and determinants; genetic risk; socio-economic status; behavioural, including lifestyle risk factors; environmental factors; as well as social, cultural, sex and gender aspects, including inequalities, should be taken into account across all aspects mentioned above. In addition, differences within and between countries and regions should also be reflected.