Leveraging multimodal data to advance Generative Artificial Intelligence applicability in biomedical research (GenAI4EU)

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Code: 37583 | Identifier Code: HORIZON-HLTH-2025-01-TOOL-03 | Programme name: 2939 | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 16/09/2025

The availability of large-scale multimodal health data, scientific information, and novel Generative AI models, combined with high-performance computing capacities offer an unprecedented opportunity for researchers to achieve breakthroughs in our understanding of disease development and to develop new predictive models for disease management, personalised treatment solutions and personalised care pathways. 

Advancing cell secretome-based therapies

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Code: 37580 | Identifier Code: HORIZON-HLTH-2025-01-TOOL-02 | Programme name: 2939 | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 16/09/2025

Secretome-based therapies have emerged as a promising alternative to cell-based therapies.

The secretome of cells is defined as the repertoire of molecules and biological factors that are secreted into the extracellular space and has been shown to be a key factor for therapeutic activity due to its paracrine effects.

The potential to manufacture, store and use secretome factors as off-the-shelf products, while maintaining the therapeutic benefits of cells but with fewer safety concerns, has placed the secretome at the forefront of regenerative medicine. Different cell secretomes or parts thereof have been the subject of clinical trials, but there is currently no regulatory-approved secretome-based therapy owing to several challenges.

Currently, for the majority of secretome-based therapies, the main bottlenecks are: the incomplete understanding of their mode of action, their reproducibility due to a lack of standardised manufacturing processes and a lack of potency- and quality assurance assays. Additional limitations are the characterisation of the bioactive factors and the optimisation of the delivery strategies.

Enhancing cell therapies with genomic techniques

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Code: 37577 | Identifier Code: HORIZON-HLTH-2025-01-TOOL-01 | Programme name: 2939 | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 16/09/2025

Therapies based on cells, stem cells or somatic cells, have been shown to be highly effective as therapeutics for a variety of health conditions.

However, bottlenecks remain which currently hamper their safe and efficient application on a large scale.

Genome- and epigenome editing have great potential to overcome some of these bottlenecks and to lead to the next-generation of cell-based therapies.

Advancing the frontier of cell-based therapy with these tools and further translation of such research into clinically viable solutions may open up a new era of innovative therapies.

Digitalisation of conformity assessment procedures of medical devices and in vitro diagnostic medical devices

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Code: 37574 | Identifier Code: HORIZON-HLTH-2025-01-IND-02 | Programme name: 2939 | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 16/09/2025

The regulations on Medical Devices (MDR) and In Vitro Diagnostic Medical Devices (IVDR) have introduced stricter regulatory requirements in view of ensuring a high level of patient safety and public health. The implementation of the new regulatory requirements still remains a challenge for manufacturers.

SMEs face particular challenges as they have limited resources to adapt to the new framework.

One of the main issues reported by manufacturers is the complexity and perceived unpredictability of the conformity assessment procedure involving a Notified Body.

Digital enablers and building blocks for Earth Observation and Satellite telecommunication for Space solutions

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Code: 37569 | Identifier Code: HORIZON-CL4-2025-02-SPACE-31 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025

This topic falls under the European Partnership on Globally Competitive Space Systems and focuses on satellite communications (SatCom), Earth Observation (EO), and new commercial space transportation solutions, as part of broader digitalisation efforts for space services. The emphasis is on accelerating the development of low- to mid-TRL technologies that enhance competitiveness, especially through digital technologies that improve data resolution, timeliness, and resilience across end-to-end SatCom and EO systems. Projects should contribute to one or more of the following outcomes: improving the performance and integration of satellite networks with terrestrial systems to maintain EU leadership in global connectivity; enabling new commercial services through digitalised space solutions; and advancing EO payloads, technologies, and data processing capabilities. Overall, the goal is to foster more flexible, reactive, and globally competitive space-based services within the EU space sector.

Optimising the manufacturing of Advanced Therapy Medicinal Products (ATMPs)

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Code: 37568 | Identifier Code: HORIZON-HLTH-2025-01-IND-01 | Programme name: 2939 | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 16/09/2025

New pioneering treatments called Advanced Therapy Medicinal Products (ATMPs), including cell and gene therapies, are at the cutting edge of medicines discovery.

Owing to their precise nature, ATMPs embody personalised medicine and reflect a shift in medicine towards potentially one-time curative therapies instead of chronic therapies that mainly cure the symptoms but not the underlying cause of diseases.

Tackling high-burden for patients and under-researched medical conditions

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Code: 37565 | Identifier Code: HORIZON-HLTH-2025-01-DISEASE-07 | Programme name: 2939 | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 16/09/2025

A number of medical conditions fail to be recognised and/or be correctly diagnosed in a significant proportion of patients.

As a consequence, they are inadequately treated and often can become a chronic and high burden for the patient.

These medical conditions, including:

1. myalgic encephalomyelitis/chronic fatigue syndrome,
2. autism,
3. gynaecological diseases,
4. low back pain,
5. other,

may be insufficiently researched even though they manifest with high prevalence.

Implementation research addressing strategies to strengthen health systems for equitable high-quality care and health outcomes in the context of non-communicable diseases (GACD)

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Code: 37560 | Identifier Code: HORIZON-HLTH-2025-01-DISEASE-06 | Programme name: 2939 | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 16/09/2025

The European Commission is a member of the Global Alliance for Chronic Diseases (GACD).

The GACD specifically addresses NCDs and supports implementation science to improve health outcomes. This topic is launched in concertation with the other GACD members (international funding agencies) and aligned with the 10^th GACD call.

ISOS Pilot Mission Detailed Design – satAPPs component

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Code: 37559 | Identifier Code: HORIZON-CL4-2025-02-SPACE-24 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025

To tackle the above expected outcomes, the following R&I actions should be addressed, taking into account the provided technical annex:

• R&I to complete ISOS Pilot mission detailed mission and system design (including relevant key technology maturation) for the satAPPs component. All relevant technologies shall reach the necessary TRL.
• R&I on technologies relevant for innovative satAPPs at TRL 6 that will be used in the context of the ISOS pilot mission to demonstrate upgrade of components’ functionalities and/or payload exchange and IOD/V experiments.
• R&I on satAPP modules specifically for hosting IOD/V experiments.
• Contribution to the overall ISOS pilot mission detail design in close cooperation with other mission components, the ISOS Pilot Mission Coordination and Support Action and the ISOS Pilot Mission Advisory Group.

ISOS Pilot Mission Detailed Design – Logistics component

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Code: 37554 | Identifier Code: HORIZON-CL4-2025-02-SPACE-23 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025

To tackle the above expected outcomes, the following R&I actions should be addressed, taking into account the provided technical annex:

• R&I to complete ISOS Pilot mission detailed mission and system design (including relevant key technology maturation) for the logistics component, demonstrating the achievement of the required TRL for all relevant technologies;
• R&I on key enabling technologies relevant for design of a logistics component that can transport cargo (i.e., satAPPs and propellant) taken from an upper stage to the HOST component;
• R&I on solutions for docking and propellant management and transfer with the HOST. Building on existing European designs is encouraged;
• Contribution to the overall ISOS pilot mission detail design in close cooperation with other mission components, the ISOS Pilot Mission Coordination and Support Action and the ISOS Pilot Mission Advisory Group.

ISOS Pilot Mission Detailed Design – HOST component

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Code: 37550 | Identifier Code: HORIZON-CL4-2025-02-SPACE-22 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025

To tackle the above expected outcomes, the following R&I actions should be addressed taking into account the provided technical annex:

• R&I to complete ISOS Pilot mission detailed mission and system design (including relevant key technology maturation) for the platform component (HOST), demonstrating the achievement of the required TRL for all relevant technologies;
• R&I on key enabling technologies relevant for design of a scalable, modular, flexible platform component, equipped with robotic manipulation, satAPPs compatibility and refuelling capability (for the HOST and the hosted servicer and logistic spacecraft), that can be extended and reconfigured to meet different demands (e.g., governmental and commercial, IOD/V and additional servicer hosting slots, robotic/manufacturing testbeds, warehouse and logistic node, etc.);
• Contribution to the overall ISOS pilot mission detail design in close cooperation with other mission components, the ISOS Pilot Mission Coordination and Support Action and the ISOS Pilot Mission Advisory Group;
• R&I on related HOST functions and applications including related operational concepts considering the use of distributed computing, multi-agent and network architectures and supported by simulations, enhancing the overall pilot mission system functionality.

ISOS Pilot Mission Detailed Design – Servicing component

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Code: 37547 | Identifier Code: HORIZON-CL4-2025-02-SPACE-21 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025

To tackle the above expected outcomes, the following R&I actions should be addressed, taking into account the provided technical annex:

• R&I to complete detailed mission and system design (including relevant key technology maturation) for the servicing component as part of the ISOS pilot mission. More specifically, projects should finalise the detailed design for this component building on current or previous developments, demonstrating the achievement of the required TRL for all relevant technologies;
• Contribution to the overall ISOS pilot mission detail design in close cooperation with the other mission components (including other servicing components), the ISOS Pilot Mission Coordination and Support Action and the ISOS Pilot Mission Advisory Group;
• R&I on related service capabilities and applications including operational concepts for servicing individual or fleets of satellites based on the functionality of the pilot mission system design. More specifically, possible use case for servicing a real EU asset is expected to be developed up to delivery of a concept of operations (CONOPS).

Digital solutions for autonomy for space transportation systems, design and simulation tools – targeting demonstration

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Code: 37544 | Identifier Code: HORIZON-CL4-2025-02-SPACE-13 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025

To tackle the above-mentioned expected outcomes, the following R&I should be addressed: R&I on advanced technologies and digital sensors for new space transportation, such as smart avionics with modularity and reusability drivers, health monitoring system and smart sensors, and structural health monitoring addressing thermo-mechanical monitoring and damage detection, ground and flight software for data management even by use of AI-algorithms.

The developments should aim at on-ground or in-orbit demonstration focusing on software and digital tools.

Support for the functioning of the Global Research Collaboration for Infectious Disease Preparedness (GloPID-R)

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Code: 37543 | Identifier Code: HORIZON-HLTH-2025-01-DISEASE-05 | Programme name: 2939 | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 16/09/2025

Recent history has illustrated the potential extent of threats posed by new or emerging infectious diseases, as well as the central importance of global collaboration and coordination to fight such regional or international challenges.

GloPID-R was established in 2013 for this reason, in response to a request for coordination by the Heads of International Research Organisations.

GloPID-R now provides a widely recognised platform for infectious disease research funders to work together to better tackle severe epidemics such as Ebola or Zika, pandemics at regional level that affect outermost regions, as well as global pandemics such as COVID-19.

Leveraging artificial intelligence for pandemic preparedness and response

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Code: 37538 | Identifier Code: HORIZON-HLTH-2025-01-DISEASE-04 | Programme name: 2939 | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 16/09/2025

The COVID-19 pandemic underscored the need of finding innovative approaches to pandemic preparedness and response, including digital solutions leveraging AI technologies.

AI is a fast-developing field, holding an enormous potential in using the multitude of data from an equally vast range of sources, which should be used for improving preparedness and response to epidemics or pandemics in the EU and Associated Countries.

Digital solutions for autonomy for space transportation systems, design and simulation tools – Digital enablers and building blocks

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Code: 37537 | Identifier Code: HORIZON-CL4-2025-02-SPACE-12 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025

To tackle the above-mentioned expected outcomes, the following R&I is expected to be addressed:

• the maturation of eco-design software tools enhancing reconfigurability in orbit
• the maturation of disruptive/game changing technologies related to digitalisation

Development of antibodies and antibody-derived proteins for the prevention and treatment of infectious diseases with epidemic potential

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Code: 37534 | Identifier Code: HORIZON-HLTH-2025-01-DISEASE-03 | Programme name: 2939 | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 16/09/2025

As shown by the COVID-19 pandemic, infectious diseases remain a major threat to health and health security in the EU and globally.

Viral disease emergence is expected to accelerate due to among other, climate change, and thus a proactive approach to the development of antiviral prophylactics and therapeutics in preparedness for future infectious disease outbreaks is needed.

The availability of antibodies and antibody-derived proteins would provide a critical preparedness measure against future health threats, due to infectious disease epidemics or pandemics.

CSA on access to European spaceports

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Code: 37529 | Identifier Code: HORIZON-CL4-2025-02-SPACE-11 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025

Testing safety and efficacy of phage therapy for the treatment of antibiotic-resistant bacterial infections

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Code: 37528 | Identifier Code: HORIZON-HLTH-2025-01-DISEASE-01 | Programme name: 2939 | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 16/09/2025

Antimicrobial resistance (AMR) has been identified by the United Nations (UN) General Assembly as a health Emergency in 2016.

AMR is contributing to morbidity and mortality increasing the burden for society and healthcare costs.

This is due to a worrying increase on the number of bacteria resistant to antibiotic treatment, causing chronic and often life-threatening infections such as wound and urinary tract infections.

The World Health Organization (WHO) lists AMR among the top 10 threats for global health and recognises that a lack of innovation is set to undermine antibiotic performance and health gains, with a major gap in the discovery of innovative antibacterial treatments.

End user-driven application of Generative Artificial Intelligence models in healthcare (GenAI4EU)

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Code: 37524 | Identifier Code: HORIZON-HLTH-2025-01-CARE-01 | Programme name: 2939 | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 16/09/2025

Healthcare professionals face important challenges related to efficiency, patient safety and provision of quality care with limited health systems’ resources.

Multimodality of health data combined with the available high-performance computing capabilities have the potential to empower effective and accurate use of trustworthy and ethical Generative AI-based solutions, augmented by other AI tools to address these challenges.

Generative AI may benefit patients, healthcare professionals and health systems.