Antimicrobial resistance and antibiotic biosynthesis in soils: developing key understanding and counteractive strategies using a One-Health approach

Opened

Code: 39373 | Identifier Code: HORIZON-MISS-2026-05-SOIL-02 | Programme name: 2939 | Sub-program: Missions | Start submission calls: 04/02/2026 | End submission calls: 23/09/2026

Soil biodiversity plays a major role in human, animal and ecosystem health. Soil microorganisms (bacteria and fungi) have been crucial in the discovery of antibiotics used in human and veterinary medicine.

However, soils can also be a hotspot for antimicrobial resistance development and can play a key role in the transfer of antimicrobial resistance genes between organisms and environmental compartments.

Antibiotic use is expected to increase globally due to the rising demand for food-producing animals, which may further exacerbate the development of antimicrobial resistance in soils.

According to the World Health Organization, antimicrobial resistance is one of the greatest threats to public health.

The driving forces for antimicrobial resistance development in soils are however understudied, as well as the role of soils in the exposure of humans and animals to antimicrobial resistance determinants. Moreover, our knowledge of antibiotics-related genes is currently limited, making it challenging to identify new compounds of interest. To better understand and combat antimicrobial resistance development in soils, a One-Health approach is needed.

Monitoring soil health in practice: equipping stakeholders to sample, analyse, and interpret soil health indicators

Opened

Code: 39370 | Identifier Code: HORIZON-MISS-2026-05-SOIL-01 | Programme name: 2939 | Sub-program: Missions | Start submission calls: 04/02/2026 | End submission calls: 23/09/2026

Soil health assessments will be key in the EU, especially with initiatives like the upcoming Soil Monitoring and Resilience Directive. Assessments will provide critical data to support adaptive management practices that optimise soil health enhancing competitiveness and resilience.

Innovation for regional rail services and new guided transport systems

Closed

Code: 39367 | Identifier Code: HORIZON-JU-ER-2026-FA6FA7-01 | Programme name: 24432 | Start submission calls: 04/02/2026 | End submission calls: 07/05/2026

Regional railways are essential as a link to other transport services but also to serve Europe’s regions, its citizen and businesses, which is why their long-term viability should be ensured. To this end, total costs of ownership are to be reduced while maintaining high service quality and operational safety. The concept to be developed will be tailored to the regional railways and will include digitalisation, automation, and the use of new and mainstream technologies.

Safety and certification guidelines and demonstration of safety components for hyperloop

Closed

Code: 39364 | Identifier Code: HORIZON-JU-ER-2026-FA7-01 | Programme name: 24432 | Start submission calls: 04/02/2026 | End submission calls: 07/05/2026

EU-Rail promote forward looking activities, tackling disruptive technologies and thinking, performing exploratory research to accelerate the pace towards radical system innovations in the guided transport modes and supporting the evolution of the Innovation Programme in scope and targets.

Boosting innovation for better assessment of the added value of innovative integrated healthcare solutions

Closed

Code: 39358 | Identifier Code: HORIZON-JU-IHI-2026-12-SINGLE-STAGE-05 | Programme name: 23667 | Start submission calls: 15/01/2026 | End submission calls: 21/04/2026

With a view to harnessing new science and technologies, this topic aims to fund pre-competitive research and innovation for novel tools, methods, technologies that will foster the development of health innovations to prevent, intercept, diagnose, treat, and manage diseases and enable recovery more efficiently.

Boosting innovation through exploitation of digitalisation and data exchange in healthcare

Closed

Code: 39355 | Identifier Code: HORIZON-JU-IHI-2026-12-SINGLE-STAGE-04 | Programme name: 23667 | Start submission calls: 15/01/2026 | End submission calls: 21/04/2026

With a view to harnessing new science and technologies, this topic aims to fund pre-competitive research and innovation for novel tools, methods, technologies that will foster the development of health innovations to prevent, intercept, diagnose, treat and manage diseases and enable recovery more efficiently.

Boosting innovation for people-centred integrated healthcare solutions

Closed

Code: 39351 | Identifier Code: HORIZON-JU-IHI-2026-12-SINGLE-STAGE-03 | Programme name: 23667 | Start submission calls: 15/01/2026 | End submission calls: 21/04/2026

With a view to harnessing new science and technologies, this topic aims to fund pre-competitive research and innovation for novel tools, methods, technologies that will foster the development of health innovations to prevent, intercept, diagnose, treat and manage diseases, and enable recovery more efficiently.

Boosting innovation through better integration of fragmented health R&I efforts

Closed

Code: 39348 | Identifier Code: HORIZON-JU-IHI-2026-12-SINGLE-STAGE-02 | Programme name: 23667 | Start submission calls: 15/01/2026 | End submission calls: 12/04/2026

With a view to harnessing new science and technologies, this topic aims to fund pre-competitive research and innovation for novel tools, methods, technologies that will foster the development of health innovations to prevent, intercept, diagnose, treat, and manage diseases and enable recovery more efficiently.

Boosting innovation for a better understanding of the determinants of health

Closed

Code: 39344 | Identifier Code: HORIZON-JU-IHI-2026-12-SINGLE-STAGE-01 | Programme name: 23667 | Start submission calls: 15/01/2026 | End submission calls: 21/04/2026

With a view to harnessing new science and technologies, this topic aims to fund pre-competitive research and innovation for novel tools, methods and technologies that will foster the development of health innovations to prevent, intercept, diagnose, treat, and manage diseases and enable recovery more efficiently.

Accordingly, applicants must assemble a collaborative public-private partnership consortium reflecting the integrative and cross-sectoral nature of IHI JU, that is capable of addressing the challenge(s) and scope of the IHI JU Specific Objective 1 ‘contribute towards a better understanding of the determinants of health and priority disease areas’, as defined in IHI JU’s legal basis and described in more detail in the IHI JU SRIA.

Cross-border renewable energy works projects

Closed

Code: 39341 | Identifier Code: CEF-E-2026-CBRENEW-WORKS | Programme name: 3569 | Sub-program: Connecting Europe Facility – Energy Infrastructure | Start submission calls: 05/02/2026 | End submission calls: 12/03/2026

This topic refers to works projects contributing to the implementation of a CB RES project. Works in the meaning of CEF Energy include the purchase, supply and deployment of components, systems and services including software, the development, construction and installation activities relating to a CB RES project, the acceptance of installations and the launching of a CB RES project.

Cross-border renewable energy studies projects

Closed

Code: 39337 | Identifier Code: CEF-E-2026-CBRENEW-STUDIES | Programme name: 3569 | Sub-program: Connecting Europe Facility – Energy Infrastructure | Start submission calls: 05/02/2026 | End submission calls: 12/03/2026

This topic refers to projects for studies contributing to the implementation of a CB RES project. Studies in the meaning of CEF Energy include activities needed to prepare cross-border RES project implementation, such as preparatory, mapping, feasibility, evaluation, testing and validation studies, including in the form of software, and any other technical support measure, including prior action to define and develop a cross-border RES project and decide on its financing, such as exploration of the sites concerned and preparation of the financial package.

Global collaboration action on climate and health in sub-Saharan Africa

Closed

Code: 39334 | Identifier Code: HORIZON-JU-GH-EDCTP3-2026-02-CH-01-two-stage | Programme name: 29117 | Start submission calls: 14/01/2026 | End submission calls: 04/03/2026

Proposals under this topic should include:

A/ Minimum one of the following:

1. Conduct a phase IIb or III clinical trial, or post-authorisation effectiveness (phase IV) trial developing a preventive or therapeutic medicine, or vaccine against the pathogens in scope, OR
2. Conduct large-scale implementation research on a validated (corresponding to Technology Readiness Level 8) medical device or novel vector control intervention for pathogens in scope in the context of integrated disease control interventions (which may include surveillance systems, early warning tools, diagnostics, and vector control innovations).

B/ In addition, proposals should address ALL of the following:

1. Where appropriate, integrate the OneHealth aspect in the research, the cross-over between human health with environmental and animal health (guidelines EU for OneHealth incorporation in climate and health). Package interventions could also be considered here.
2. Encompass primary health care systems, community health workers and the community into the study.
3. Include underserved and vulnerable populations such as children under five, pregnant women, elderly people, people with co-morbidities, immunocompromised people, and displaced populations including those living in informal settlements in urban or peri-urban areas as relevant.

C/ In addition, the proposals should address at least two of the following:

1. Include indigenous populations as defined per national/regional context.
2. Study the impact of climate change on supply chains and access to medical countermeasures.
3. Involve local, regional or national health and climate authorities/policymakers, bridging the gap between research and policymaking.
4. Integrate research in national adaptation plans and National Health Emergency Plans.
5. Include adaptations of primary health care systems to climate change, for example infrastructural improvements or the training of the primary care workforce.