Pragmatic clinical trials to optimise immunotherapeutic interventions for patients with refractory cancers

Opened

Code: 39554 | Identifier Code: HORIZON-MISS-2026-02-CANCER-03 | Programme name: 2939 | Sub-program: Missions | Start submission calls: 10/02/2026 | End submission calls: 15/09/2026

While cancer research and innovation have generated novel treatment options, patients with refractory cancers across Europe need access to more effective, affordable and tailored cancer immunotherapeutic interventions which keep up with increasing demands in a complex and fragmented oncology healthcare landscape with spiralling healthcare costs.

Development of a research capacity building programme on cancer with and for Ukraine

Opened

Code: 39551 | Identifier Code: HORIZON-MISS-2026-02-CANCER-06 | Programme name: 2939 | Sub-program: Missions | Start submission calls: 10/02/2026 | End submission calls: 15/09/2026

Ukraine has a very high cancer burden with more than 155,000 new diagnoses every year. The country has also one of the highest childhood cancer mortality rates globally.

Disparities in access and quality of cancer care in Ukraine were high before Russia’s unprovoked aggression and worsened because of the conflict, which has also led to increased cancer mortality and morbidity, due to discontinuation of treatments and shortage of medical supplies.

Microbiome for early cancer prediction before the onset of disease

Opened

Code: 39548 | Identifier Code: HORIZON-MISS-2026-02-CANCER-02 | Programme name: 2939 | Sub-program: Missions | Start submission calls: 10/02/2026 | End submission calls: 15/09/2026

This topic will contribute to the achievement of the EU Cancer Mission’s objective to achieve better cancer prevention and early detection.

The focus is on the development of validated microbiome tools, an assessment of predispositions, the comparison with other predictive tools and risk modelling approaches.

Boosting mental health of young cancer survivors through the European Cancer Patient Digital Centre (ECPDC)

Opened

Code: 39544 | Identifier Code: HORIZON-MISS-2026-02-CANCER-05 | Programme name: 2939 | Sub-program: Missions | Start submission calls: 10/02/2026 | End submission calls: 15/09/2026

As part of its citizens engagement activities, the EU Cancer Mission has launched a dialogue with young cancer survivors, to better understand the specific needs and challenges faced during and after treatment.

Mental health has been systematically highlighted as a major concern, stressing the importance of access to quality psychosocial support including through virtual, digital means along the different stages of the patient’s journey, at diagnosis, during and after treatment.

The communication on a Comprehensive approach to mental health adopted by the European Commission on 7 June 2023 calls for the establishment of a platform to boost mental health of young cancer survivors.

Virtual Human Twin (VHT) Models for Cancer Research

Opened

Code: 39540 | Identifier Code: HORIZON-MISS-2026-02-CANCER-01 | Programme name: 2939 | Sub-program: Missions | Start submission calls: 10/02/2026 | End submission calls: 15/09/2026

Virtual human twins (VHTs) are digital representations and in-silico models of an individual’s health and disease at different levels of the human anatomy (e.g. cells, tissues, organs or organ systems) for the prevention, prediction, screening, diagnosis and treatment of a disease, as well as the selection and personalisation of intervention options.

Earlier and more precise palliative care

Opened

Code: 39536 | Identifier Code: HORIZON-MISS-2026-02-CANCER-04 | Programme name: 2939 | Sub-program: Missions | Start submission calls: 10/02/2026 | End submission calls: 15/09/2026

This topic will contribute to the achievement of the EU Cancer Mission’s objective to provide better quality of life for cancer patients, their families and carers. The focus is on the development of innovative models for earlier, more precise and better integrated palliative care.

Call 1 – “Collection & Valorisation”

Closed

Code: 39533 | Identifier Code: UPSTREAM | Programme name: 2939 | Start submission calls: 15/01/2026 | End submission calls: 16/03/2026

Aim. Provide targeted financial support and technical assistance to associated regions to replicate, scale and localise UPSTREAM solutions for monitoring, prevention, removal and valorisation of plastic litter and microplastics in rivers and connected waters.

ERC PROOF OF CONCEPT GRANTS

Closed

Code: 39531 | Identifier Code: ERC-2026-POC | Programme name: 2939 | Sub-program: European Research Council (ERC) | Start submission calls: 20/01/2026 | End submission calls: 17/03/2026

The ERC Proof of Concept Grants aim at facilitating exploration of the commercial and social innovation potential of ERC funded research and are therefore available only to Principal Investigators whose proposals draw substantially on their ERC funded research.

Bridging the gap between disaster risk management and climate adaptation

Opened

Code: 39528 | Identifier Code: HORIZON-MISS-2026-01-CLIMA-04 | Programme name: 2939 | Sub-program: Missions | Start submission calls: 04/02/2026 | End submission calls: 23/09/2026

The successful proposal will contribute to the implementation of the EU Mission on Adaptation to Climate Change, the Preparedness Union Strategy and the upcoming European Climate Adaptation Plan, by facilitating the interaction between the actors of the Climate Adaptation and Disaster Risk Management at European, national and regional scales.

Proposals are expected to contribute to all of the following outcomes:

• The Climate Adaptation and Disaster Risk Management communities at European level are brought together to develop inter- and transdisciplinary methodological approaches, constructing and disseminating joint knowledge.
• The knowledge and understanding of the common aspects for Disaster Risk Management preparedness and climate change adaptation are enhanced, including the question of responsibility and accountability.
• The terminology and understanding of the risks and the possible solutions are aligned for Disaster Risk Management and Adaptation and hence local resilience to climate change is improved.

Improving climate resilience of navigable inland waterways, their surroundings and related water infrastructure

Opened

Code: 39524 | Identifier Code: HORIZON-MISS-2026-01-CLIMA-06 | Programme name: 2939 | Sub-program: Missions | Start submission calls: 04/02/2026 | End submission calls: 23/09/2026

Successful proposals will support the implementation of the EU Adaptation Strategy, the EU Mission on Adaptation to Climate Change, the European Water Resilience Strategy, the EU Preparedness Strategy and the upcoming European Climate Adaptation Plan. Proposals are expected to contribute to all of the following outcomes:

• Navigable inland waterways, their surroundings and related infrastructure are managed in a more integrated and sustainable manner across Europe and become more climate-resilient
• Climate and environmental risks to water infrastructure (e.g. droughts, flooding, slow onset events, ecological degradation and cascading and compound events) are more effectively addressed in a systemic way. Safe, efficient and reliable navigability conditions are improved.
• Cost-efficient and environmentally friendly measures — especially nature-based solutions — are identified with the involvement of stakeholders. They improve climate resilience of inland waterways while supporting integrated co-benefit and avoiding competing water uses, including between countries and regions.

Facilitating implementation of actionable solutions for climate adaptation of regions and local authorities

Opened

Code: 39521 | Identifier Code: HORIZON-MISS-2026-01-CLIMA-02 | Programme name: 2939 | Sub-program: Missions | Start submission calls: 04/02/2026 | End submission calls: 23/09/2026

The successful proposal will contribute to the implementation of the EU Mission on Adaptation to Climate Change and the upcoming European Climate Adaptation Plan. Proposals are expected to contribute to all of the following outcomes:

• The wide range of solutions tested and deployed in the context of the Adaptation Mission and the good practices emerged in its Community of Practice are harvested, assessed, structured and systematised to support the implementation of the Mission.
• Regional and local authorities can access, in the local language, the latest and most actionable solutions for climate adaptation relevant to their (climatic) conditions.
• Adaptation solutions stemming from research and innovation are ready for replication and scale-up, contributing to the delivery of the Adaptation Mission and acceleration of adaptation efforts across Europe. Legacy of the knowledge created by the Mission is also ensured.
• Knowledge and understanding of the policy implications of adaptation solutions is increasingly utilised in the policy cycles at EU, national, and regional and local levels.

Standardising and supporting climate services for climate adaptation

Opened

Code: 39519 | Identifier Code: HORIZON-MISS-2026-01-CLIMA-03 | Programme name: 2939 | Sub-program: Missions | Start submission calls: 04/02/2026 | End submission calls: 23/09/2026

The successful proposal will support the implementation of the EU Mission on Adaptation to Climate Change and the upcoming European Climate Adaptation Plan. Projects are expected to contribute to all of the following outcomes:

• The methodology for identifying, selecting and consolidating global and regional reference climate data sets and scenarios is advanced and their consistent use across the EU in relation to climate adaptation is supported.
• Standardisation and quality of climate services across the EU are improved, and their uptake is enhanced.
• Climate services and best practices are used effectively to inform climate adaptation policies and decisions