SSbD bio-based fertilising and crop protection products can offer more resilient and sustainable solutions creating an added-value partnership between agriculture and industry both upstream (for feedstock supply) and downstream (for the use of sustainable and efficient bio-based products). However, when scaling-up, challenges need to be solved in terms of process efficiency and robustness against feedstock variability, formulations stability and efficacy on the field (also in consideration of climate change effects and different soil conditions), and cost competitiveness.

Proposals under this topic should:

• Demonstrate (at TRL 8) the efficient industrial production of SSbD bio-based solutions as alternatives to current fertilising and/or crop protection products. Bioactive molecules and/or biotechnology solutions for bio-fertilisers, bio-stimulants and/or pest/disease control (e.g., bioherbicides, biopesticides, bioinsecticides), or a combination thereof, are in scope. Products in scope can be applicable at any crop(s) cycle stage.
• Validate (at TRL 6 and above) at scale the produced bio-alternatives into the formulation of end-product(s) and test their agronomic efficiency, safety and sustainability to prove the achievement of similar or improved properties compared to defined benchmarks available in the market (synthetic and/or mineral). In case of bio-based fertilisers, put in place a solid production validation procedure to ensure reduced nutrient variability of the N/P/K content in end-products.
• Test the developed product(s) with primary producers on the field (demo farms) for selected crops and monitor their effects on soil health and quality, as well as on water. Cover different climatic and soil conditions, taking into account different farming systems, including organic agriculture. If controlled release mechanisms are employed, the proposed innovations should avoid microplastics accumulation in soil.

In addition to the specific requirements applicable for the type of action, as described in section 2.2.3.1 of the CBE JU Annual Work Programme 2026, proposals under this topic should:

• As part of the multi-actor approach (MAA), ensure adequate involvement of all key actors in the value chains relevant for this topic and across the sustainable circular bio-based system, including primary producers to support the acceptance and adoption of developed products.
• Address compliance with relevant EU regulatory frameworks related to manufacturing and entry-to-market of targeted bio-based alternative(s). This includes performing a sanitary and environmental risk assessment to prevent the introduction of harmful biological and/or chemical contaminants into soil, crops and the food chain, while also safeguarding human health and soil ecosystems. Include a task to identify potential regulatory gaps and provide recommendations to overcome potential bottlenecks.
• Include a task to apply the SSbD framework, developed by the European Commission for the assessment of targeted bio-based product(s). For more information on the SSbD framework and criteria, refer to Safe and sustainable by design.
• Ensure complementarities with past and ongoing R&I projects addressing similar challenges, including projects funded under Horizon 2020 / Horizon Europe (under Cluster 6 and other Clusters of Horizon Europe) and BBI JU/CBE JU projects.