Different treatment modalities are available for various cancers, however, the differing biology of cancers as well as the differing efficacy of treatment modalities dictate rather patient-specific approaches. Multi-modal therapies have been shown to be of high value in this respect and there is a strong need to increase the therapeutic arsenal of such multi-modal therapies and to tailor the treatment approach to the individual patient.

Proposals should facilitate the development of new health technologies and integrate them with (possibly adapted) current therapy concepts, to create and explore multi-modal therapies personalised to the needs of the individual patient. Applicant consortia should pursue different therapeutic strategies and combine at least two cancer treating modalities1 (supported by a sound scientific rationale in the application).

The proposed R&I activities should include development of research protocols for multi-modal therapies expected to have a significant potential to create patient benefits. These protocols should be explored via early clinical studies with sufficient sample size and statistical power to assess safety and efficacy and demonstrate feasibility of the chosen multi-modal approach.