Programme Category
Programme Name
Programme Description
The Global Health EDCTP3 Joint Undertaking (GH EDCTP3) builds on the first and second European and Developing Countries Clinical Trials Partnership programmes. This new joint undertaking (JU) is a partnership between the EU and the EDCTP Association, whose members are several European and African countries. The partnership will deliver new solutions for reducing the burden of infectious diseases in SSA and strengthen research capacities to prepare and respond to re-emerging infectious diseases in this region and across the world.
Identifier Code
Call
Summary
Proposals under this topic should include:
A/ Minimum one of the following:
- Conduct a phase IIb or III clinical trial, or post-authorisation effectiveness (phase IV) trial developing a preventive or therapeutic medicine, or vaccine against the pathogens in scope, OR
- Conduct large-scale implementation research on a validated (corresponding to Technology Readiness Level 8) medical device or novel vector control intervention for pathogens in scope in the context of integrated disease control interventions (which may include surveillance systems, early warning tools, diagnostics, and vector control innovations).
B/ In addition, proposals should address ALL of the following:
- Where appropriate, integrate the OneHealth aspect in the research, the cross-over between human health with environmental and animal health (guidelines EU for OneHealth incorporation in climate and health). Package interventions could also be considered here.
- Encompass primary health care systems, community health workers and the community into the study.
- Include underserved and vulnerable populations such as children under five, pregnant women, elderly people, people with co-morbidities, immunocompromised people, and displaced populations including those living in informal settlements in urban or peri-urban areas as relevant.
C/ In addition, the proposals should address at least two of the following:
- Include indigenous populations as defined per national/regional context.
- Study the impact of climate change on supply chains and access to medical countermeasures.
- Involve local, regional or national health and climate authorities/policymakers, bridging the gap between research and policymaking.
- Integrate research in national adaptation plans and National Health Emergency Plans.
- Include adaptations of primary health care systems to climate change, for example infrastructural improvements or the training of the primary care workforce.
Detailed Call Description
Climate-sensitive infectious diseases are defined in scope of this call as diseases whose incidence, prevalence, or intensity is negatively impacted by climate change and includes the vector- and water-borne pathogens in the scope of the Global Health EDCTP3 SRIA.
Proposals are encouraged to integrate climate-epidemiological models integrating humans, animals and ecosystems under different climate scenarios and to indicate how it will contribute to improving the preparedness of health security related to climate sensitive pathogens in (Southern) EU.
Preclinical studies are considered out of scope of the topic.
For all Global Collaboration Actions such as this topic, proposals submitted are expected to leverage financial and/or in-kind contributions from contributing partners. Proposals should define the activities of their project in its entirety, including details of the component(s) for which Global Health EDCTP3 funding is requested and the component(s) that are to be financed by contributing partners. Each contribution should be well described and budgeted in each proposal, so that the activities and related costs that are covered by the in-kind or financial contribution(s) are clearly identified.
Applicants are to provide data on the impact of climate change on the chosen disease, and how the proposed study would ameliorate the negative impact.
Applicants will be expected to include a fair representation of health and climate experts and One Health experts in their consortium composition, as relevant, and provide methodologies for translating research findings into public health/climate practice and policy guidelines and are encouraged to follow guidance provided in the EDCTP Knowledge Hub Research into Policy Toolkit. Multidisciplinary approaches with the integration of adjacent sectors are encouraged (i.e. nutrition, IPC/WASH, etc.).
The applicants are encouraged to consider the latest innovations and advances in the clinical trial design and research methods in order to evaluate promising interventions allowing shorter development timings. Applicants are also encouraged to follow the WHO Guidance for best practices for clinical trials.
Proposals should engage communities and relevant stakeholders, most notably (local) key opinion leaders, researchers, health care professionals, policy makers, public health authorities and end-users.
Call Total Budget
Financing percentage by EU or other bodies / Level of Subsidy or Loan
Global Health EDCTP3 estimates that a JU contribution of up to €5.000.000 to support 5 fellows per project, to be matched by an equal or greater financial and/or inkind contribution from other contributing partners, would allow the outcomes of this topic to be addressed appropriately.
Thematic Categories
- Health
- Research, Technological Development and Innovation
Eligibility for Participation
- Central Government
- Legal Entities
- Local Authorities
- Other Beneficiaries
- Private Bodies
- Researchers/Research Centers/Institutions
Eligibility For Participation Notes
For details on the process on becoming a Global Health EDCTP3 contributing partner, please consult the Guide for contributing partners. In case of in-kind contribution (even combined with financial contribution), contributing partners become a part of the applicant consortium and participate in the project, as appropriate i.e. as beneficiaries or affiliated entities in the meaning of Article 8 of the Horizon Europe model grant agreement. Also, Global Health EDCTP3 contributing partners can be a country, an international organisation or any public or private legal entity, other than the Global Health EDCTP3 members or their constituent or affiliated entities (please consult the Guide for contributing partners).
For all projects under this topic, if the coordinator is not from a country in SSA, the designation of a scientific project leader with the roles as described in the introduction is mandatory. A work package on ‘scientific project leadership’ must be included in the proposals and budget needs to be provided for this activity.
Applicants are reminded of the expectation that proposals should come from research consortia with a strong representation of institutions and researchers from SSA countries, including involvement of Franco/Lusophone countries, if possible. Collaboration with other international research groups with relevant experience is very much encouraged. Applicants are also reminded of the expectation of reaching out to organisations in countries with relatively lower research capacities. All projects funded under this topic are strongly encouraged to participate in networking and joint activities, as appropriate.
The above topic includes additional specific conditions, which are described in the Global Health EDCTP3 Joint Undertaking Work Programme 2026 (the link can be found under the “Further information” section of this email).