Proposals under this topic should:

• Demonstrate innovative processes for the extraction and/or production of proteins for application as nutritional food, starting from alternative sources. The scope covers proteins from plants, invertebrates, microorganisms, fungi, aquatic biomass, fermentation of bio-based feedstock (including biogenic gaseous carbon). Proposals should target nutritional proteins for food; the co-production of other bio-based product(s) including feed is also in scope via the cascading approach. Pure proteins, protein-rich mixtures and protein-enriched ingredients are in scope.
• Address efficient and cost-effective downstream separation and purification processes (when applicable), to meet the targeted quality and stability for final applications.
• Demonstrate nutritional adequacy of the targeted product(s) and their effect on food formulation(s) according to established testing procedures. Additional properties (e.g., prevention of intolerances/allergies, improved digestibility, etc…) are also in scope depending on the application.
• Address resource efficiency and circularity aspects to increase economic and socio-environmental added value. When pursuing circular models, ensure that neither pathogens nor contaminants are injected back in the loop, to ensure no negative toxicological effects.

In addition to the specific requirements applicable for the type of action, as described in section 2.2.3.1 of the CBE JU Annual Work Programme 2025, proposals under this topic should:

• Test the safety of developed proteins and formulations through toxicological tests, in line with EU regulatory requirements and EFSA guidelines. Moreover, identify potential regulatory gaps and provide recommendations to overcome potential bottlenecks.
• Include a task on consumer awareness and acceptance: involve end-users (including consumers) starting from the early stages to assess market acceptance of the novel proteins and incorporate insights in product development.
• Ensure complementarities with past and ongoing R&I projects addressing similar challenges, including projects funded under Horizon 2020 / Horizon Europe and by the BBI JU / CBE JU.