Proposals under this topic should:

• Identify the existing bottlenecks in the switch to continuous process(es), how the proposed innovative approach can overcome challenges of targeted process(es), which are currently only operating in batch or fed-batch mode, and specify the advantages of switching to continuous.
• Demonstrate continuous biotech process(es) (microbial, cell factories and/or enzymatic) for the sustainable production of bio-based chemicals, materials and/or ingredients addressing identified bottlenecks.
• Together with addressing continuous upstream processing (encompassing biocatalysis optimisation), demonstrate integration of efficient DSP systems to achieve high purity, in compliance with final applications requirements, while also facilitating/not hindering the continuous upstream operation. Focus on one or more bio-based chemicals, materials and/or ingredients with high market potential.
• Address resource/energy efficiency and circularity by applying process intensification and by valorising upstream and downstream side-streams (e.g., water, fermentation media, exhausted cells, etc…).

In addition to the specific requirements applicable for the type of action, as described in section 2.2.3.1 of the CBE JU Annual Work Programme 2025, proposals under this topic should:

• Implement on-line monitoring and control systems including (if relevant) advanced AI/digital tools.
• Include a task to apply the safe-and-sustainable-by-design (SSbD) framework, developed by the European Commission. Under this context, projects are expected to also contribute with and develop recommendations that can advance further the application of the SSbD framework
• Ensure complementarities with past and ongoing R&I projects, including projects funded under Horizon 2020 / Horizon Europe and by the BBI / CBE JU.