AI-generated digital twins for science

Opened

Programme Category

EU Competitive Programmes

Programme Name

Horizon Europe (2021-2027)

Programme Description

Horizon Europe is the European Union (EU) funding programme for the period 2021 – 2027, which targets the sectors of research and innovation. The programme’s budget is around € 95.5 billion, of which € 5.4 billion is from NextGenerationEU to stimulate recovery and strengthen the EU’s resilience in the future, and € 4.5 billion is additional aid.

Programme Details

Identifier Code

HORIZON-INFRA-2025-01-TECH-04

Call

AI-generated digital twins for science

Summary

The aim is to use generative artificial intelligence (AI), in line with the GenAI4EU initiative and other key EU initiatives, like the Apply AI strategy, to deliver digital twins of complex real-world systems that advance the state-of-art of European research infrastructures and show transformative potential in their operations.

The solutions should pave the way for new methods to conduct research by the RIs through AI generated and powered digital twins.

They should propose suitable setups for creation of new digital twins or enhancing existing ones, already available within the scientific communities and relevant research infrastructures and for which an existing baseline on generative Artificial Intelligence models exists, the required data fusions, visualisations and execution of the workflows.

The focus is on key impact sectors, such as healthcare (including mental health), transportation, agriculture, environment or manufacturing, or other fields related to the Clean Industrial Deal, in line with the European objectives seeking to leverage AI to address societal challenges, improve public services and drive inclusive economic growth.

The proposed solutions, underpinning the provision of improved and advanced future services, should support RIs in new areas of research and/or a wider community of users, including clearly identified and relevant industrial, scientific or policy users and enhance the potential of the RIs in addressing EU’s policy objectives and socio-economic challenges.

The proposed solutions should, at least in part, be demonstrated in a relevant environment that can lead to sustainable production and include a cost estimate for the operations.

Detailed Call Description

The proposals should cover all of the following aspects:

  • Demonstrate the ability to setup complex modelling and digital twin setups using generative AI in line with the GenAI4EU initiative and other key EU initiatives, like the Apply AI strategy.
  • Ensure a data driven approach in which new simulations and Digital Twins are set up and demonstrate the chosen approach to work in at least three different application scenarios.
  • Enable non-technical decision makers to express scenarios for challenges to be translated into impactful simulations, making use of existing digital twins, models and data sources.
  • Demonstrate trustworthiness/reliability in the use of AI and practice clear and open communication of AI use and impact to users.

Additionally, the proposals should also include work on some of the following points:

  • Best practices to use AI to generate digital twins and their setup.
  • Contribute to the European AI Factories and their abilities to facilitate large scale AI setups.
  • Demonstrate that proposed solutions work for at least two different scientific domains to highlight common principles and best practices in this approach.

Call Total Budget

€40.00 million

Financing percentage by EU or other bodies / Level of Subsidy or Loan

100%

Expected EU contribution per project:  between €8.00 and €10.00 million.

Thematic Categories

  • Agriculture - Farming - Forestry
  • Agriculture - Food
  • Energy
  • Environment and Climate Change
  • Health
  • Information and Communication Technologies
  • Information Technology
  • Processing
  • Research, Technological Development and Innovation
  • Rural development
  • Space
  • Telecommunications
  • Transport

Eligibility for Participation

  • Educational Institutions
  • Large Enterprises
  • Legal Entities
  • Natual person / Citizen / Individual
  • Non Profit Organisations
  • Other Beneficiaries
  • Private Bodies
  • Researchers/Research Centers/Institutions
  • Services Providers
  • Small and Medium Enterprises (SMEs)
  • Training Centres

Eligibility For Participation Notes

Subject to restrictions for the protection of European communication networks.

A number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon Europe projects.

Call Opening Date

06/05/2025

Call Closing Date

18/09/2025

National Contact Point(s)

Research and Innovation Foundation

Address: 29a Andrea Michalakopoulou, 1075 Nicosia, P.B. 23422, 1683 Nicosia
Telephone: +357 22205000
Fax: +357 22205001
Email: support@research.org.cy
Websitehttps://www.research.org.cy/en/